Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

509 questions · 521 findings · 45 reviews

No studies found 87 · 16.7%GRADE not reported 61 · 11.7%Very low 166 · 31.9%Low 120 · 23%Moderate 73 · 14%High 14 · 2.7%

QUETIAPINE vs Typical antipsychotics

Global state: No clinically significant response (as defined by the original studies) · patients with schizophrenia

Quetiapine showed no clear difference in global state No clinical significant response as defined by the… compared with typical antipsychotics (moderate certainty).

1 finding from 1 review

Benzodiazepines vs antipsychotics

Desired sedation ‐ ultra short term ‐ asleep at 12 hours · patients with schizophrenia

BENZODIAZEPINES showed no clear difference in desired sedation ‐ ultra short term ‐ asleep at 12 hours compared with ANTIPSYCHOTICS (low certainty).

1 finding from 1 review

Benzodiazepines vs antipsychotics

No clinically important response to treatment ‐ ultra short term (at 12 hours) · patients with schizophrenia

It is very uncertain whether BENZODIAZEPINES changes no clinically important response to treatment ‐ ultra short term (at… compared with ANTIPSYCHOTICS (very low certainty).

2 findings from 1 review

Benzodiazepines vs antipsychotics

No clinically important response to treatment ‐ short term · patients with schizophrenia

It is very uncertain whether BENZODIAZEPINES changes no clinically important response to treatment ‐ short term compared with ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

Benzodiazepines vs antipsychotics

Unacceptability of treatment (drop-outs / leaving study early) · patients with schizophrenia

It is very uncertain whether BENZODIAZEPINES changes leaving the study early due to any reason (overall acceptability of… compared with ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

Benzodiazepines vs antipsychotics

Adverse effects (drop‐outs due to adverse effects4) · patients with schizophrenia

It is very uncertain whether BENZODIAZEPINES changes leaving the study early due to adverse effects (overall tolerability… compared with ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

Levomepromazine vs Typical antipsychotics

Behaviour: Leaving the study early (short‐term) · patients with schizophrenia

Levomepromazine showed no clear difference in leaving the study early ‐ short term ‐ any reason compared with typical antipsychotics (low certainty).

1 finding from 1 review