Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

704 questions · 710 findings · 81 reviews · Headline outcomes only

No studies found 227 · 32%GRADE not reported 38 · 5.4%Very low 178 · 25.1%Low 178 · 25.1%Moderate 80 · 11.3%High 9 · 1.3%

FXIII: Prophylactic trials: intervention vs inactive control

Arterial thromboembolic events Post‐operatively · the prevention and treatment of bleeding in patients without haemophilia

FXIII: Prophylactic trials: intervention showed no clear difference in arterial thromboembolic events Up to 5 to 7 weeks post‐operatively compared with inactive control (low certainty).

3 findings from 1 review

FIBRINOGEN: Therapeutic trials: intervention vs inactive control

All‐cause mortality In‐hospital mortality up to 30 days post‐operatively · the prevention and treatment of bleeding in patients without haemophilia

FIBRINOGEN: Therapeutic trials: intervention showed no clear difference in all‐cause mortality In‐hospital mortality up to 30 days… compared with inactive Control (low certainty).

1 finding from 1 review

FXIII: Prophylactic trials: intervention vs inactive control

Venous thromboembolic events · the prevention and treatment of bleeding in patients without haemophilia

FXIII: Prophylactic trials: intervention showed no clear difference in venous thromboembolic events ‐ Up to 5 to 7 weeks post‐operatively compared with inactive control (low certainty).

2 findings from 1 review

FXIII: Prophylactic trials: intervention vs inactive control

Venous thromboembolic events Up to 30 days post‐operatively · the prevention and treatment of bleeding in patients without haemophilia

FXIII: Prophylactic trials: intervention showed no clear difference in venous thromboembolic events Up to 30 days post‐operatively compared with inactive control (low certainty).

1 finding from 1 review

FIBRINOGEN: Therapeutic trials: intervention vs inactive control

All‐cause mortality Up to 28 days post‐operatively · the prevention and treatment of bleeding in patients without haemophilia

FIBRINOGEN: Therapeutic trials: intervention showed no clear difference in all‐cause mortality Up to 46 days post‐operatively compared with inactive Control (high certainty).

1 finding from 1 review

FIBRINOGEN: Therapeutic trials: intervention vs haemostatically active control

All‐cause mortality Up to 28 days post‐operatively · the prevention and treatment of bleeding in patients without haemophilia
2 findings from 1 review

Electrical stimulation vs Placebo / sham solution

Participants with improvement in urgency urinary incontinence · Adults with overactive bladder (OAB)

Electrical stimulation showed no clear difference in participants with improvement in urgency urinary incontinence compared with placebo or sham treatment (low certainty).

1 finding from 1 review