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What do systematic reviews say?

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Evidence found and GRADE certainty

401 questions · 403 findings · 75 reviews · Headline outcomes only

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No studies found 79 · 19.6%GRADE not reported 18 · 4.5%Very low 91 · 22.6%Low 110 · 27.3%Moderate 79 · 19.6%High 26 · 6.5%

Pexastimogene devacirepvec (Pexa‐Vec) plus best supportive care vs best supportive care

Disease progression · participants with advanced hepatocellular carcinoma

It is very uncertain whether pexastimogene devacirepvec (Pexa‐Vec) plus best supportive care changes proportion of people with disease progression compared with best supportive care alone (very low certainty).

1 finding from 1 review

Subfascial endoscopic perforator vein surgery (SEPS) + compression vs compression alone

The proportion of pressure ulcers healed · people with venous leg ulcers

Subfascial endoscopic perforator vein surgery (SEPS) + compression may leads to higher proportion with ulcers healed at 24 months compared with compression alone (low certainty).

1 finding from 1 review

Subfascial endoscopic perforator vein surgery (SEPS) + compression vs compression alone

Recurrence of ulcers · people with venous leg ulcers

It is very uncertain whether subfascial endoscopic perforator vein surgery (SEPS) + compression changes ulcer recurrence at 24 months compared with compression alone (very low certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Overall survival · palliative participants with esophageal and GE‐junction carcinoma

Summary of findings table: chemotherapy or targeted therapy agent(s)… leads to lower overall survival compared with control intervention alone (high certainty).

1 finding from 1 review

Summary of findings table (subcomparison 2): second‐line chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Overall survival · palliative participants with esophageal and GE‐junction carcinoma previously treated with chemotherapy

Summary of findings table (subcomparison 2): second‐line… probably leads to lower overall survival compared with control intervention alone (moderate certainty).

1 finding from 1 review

Summary of findings table (subcomparison 2): second‐line chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Progression‐free survival · palliative participants with esophageal and GE‐junction carcinoma previously treated with chemotherapy

Summary of findings table (subcomparison 2): second‐line… may leads to lower progression‐free survival compared with control intervention alone (low certainty).

1 finding from 1 review

Summary of findings table (subcomparison 2): second‐line chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Toxicity · palliative participants with esophageal and GE‐junction carcinoma previously treated with chemotherapy

It is very uncertain whether summary of findings table (subcomparison 2): second‐line… changes toxicity compared with control intervention alone (very low certainty).

1 finding from 1 review

Summary of findings table (subcomparison 3): chemotherapy agent(s) plus control intervention vs control intervention

Overall survival · palliative participants with esophageal and GE‐junction carcinoma

Summary of findings table (subcomparison 3): chemotherapy agent(s)… probably leads to lower overall survival compared with control intervention alone (moderate certainty).

1 finding from 1 review