Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,801 questions · 4,079 findings · 473 reviews

No studies found 669 · 16.4%GRADE not reported 852 · 20.9%Very low 738 · 18.1%Low 903 · 22.1%Moderate 716 · 17.6%High 201 · 4.9%

Ultrasound‐assisted catheter‐directed thrombolysis plus standard intravenous heparinisation vs standard intravenous heparinisation

All‐cause mortality (90‐day) · people with intermediate‐risk (submassive) APE

It is very uncertain whether ultrasound‐assisted catheter‐directed thrombolysis plus standard… changes all‐cause mortality (90‐day) compared with standard intravenous heparinisation (very low certainty).

1 finding from 1 review

Ultrasound‐assisted catheter‐directed thrombolysis plus standard intravenous heparinisation vs standard intravenous heparinisation

Treatment‐associated minor haemorrhage ( · people with intermediate‐risk (submassive) APE

It is very uncertain whether ultrasound‐assisted catheter‐directed thrombolysis plus standard… changes treatment‐associated minor haemorrhage ( compared with standard intravenous heparinisation (very low certainty).

1 finding from 1 review

Ultrasound‐assisted catheter‐directed thrombolysis plus standard intravenous heparinisation vs standard intravenous heparinisation

Recurrent APE requiring retreatment or change to a different APE treatment ( · people with intermediate‐risk (submassive) APE
1 finding from 1 review

Composite resin with a beveled cavity margin vs Composite resin with no bevel (butt-joint margin)

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; no bevel had twice the failure rate in the review narrative.

1 finding from 1 review

Hall technique vs Compomer restoration or non-restorative caries treatment

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; the review reports this three-arm comparison but tabulates only compomer failure.

1 finding from 1 review

Metal-free single crowns (full-contour zirconia) vs Composite strip crown

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; failure rates were 3.3% and 15%.

1 finding from 1 review

Composite resin with etch-and-rinse (total-etch) adhesion vs Composite resin with self-etch adhesion (same universal adhesive)

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; etch-and-rinse had a higher tabulated failure rate.

1 finding from 1 review

Composite resin vs High-viscosity GIC and bulk-fill composite resins

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; tabulated failure rates ranged from 0% to 2.9%.

1 finding from 1 review

Glass carbomer vs Resin-modified glass-ionomer cement + composite resin (modified open-sandwich restoration)

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; glass carbomer had the highest tabulated failure range.

1 finding from 1 review

GIC with cavity conditioner vs GIC without cavity conditioner

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; the review states cavity conditioner did not improve success.

1 finding from 1 review

HVGIC bilayer insertion and surface coating protocols vs Alternative HVGIC insertion and surface coating protocols

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; bilayer placement and nanofilled coating were described as improving survival.

1 finding from 1 review

Systemic corticosteroids vs placebo or control

Mortality Mortality at latest · preterm infants with chronic lung disease

Systemic corticosteroids (dexamethasone or hydrocortisone) leads to lower mortality at latest reported age compared with control (placebo or nothing) (high certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo or control

Bronchopulmonary dysplasia/chronic lung disease · preterm infants with chronic lung disease

Systemic corticosteroids (dexamethasone or hydrocortisone) probably leads to lower BPD at 36 weeks' PMA compared with control (placebo or nothing) (moderate certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo or control

Death or bronchopulmonary dysplasia at 36 weeks PMA · preterm infants with chronic lung disease

Systemic corticosteroids (dexamethasone or hydrocortisone) probably leads to lower mortality or BPD at 36 weeks' PMA compared with control (placebo or nothing) (moderate certainty).

1 finding from 1 review