Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only

No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%

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PTFE vs PTFE with vein cuff

Secondary patency (24 months) · people with peripheral vascular disease requiring below‐knee femoro‐popliteal bypass surgery

It is very uncertain whether PTFE changes secondary patency (24 months) compared with PTFE with vein cuff (very low certainty).

1 finding from 1 review

PTFE vs PTFE with vein cuff

Limb salvage · people with peripheral vascular disease requiring below‐knee femoro‐popliteal bypass surgery

PTFE showed no clear difference in limb salvage (24 months) compared with PTFE with vein cuff (low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants

All allergic disease ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes all allergic disease ‐ childhood (incidence) compared with human milk feeding ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs cow's milk formula

Food allergy ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes food allergy ‐ childhood (incidence) compared with cow's milk formula ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs cow's milk formula

Cow's milk allergy ‐ infancy (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes cow's milk allergy ‐ infancy (incidence) compared with cow's milk formula ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs cow's milk formula

Cow's milk allergy ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes cow's milk allergy ‐ childhood (incidence) compared with cow's milk formula ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants

Asthma ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes asthma ‐ childhood (incidence) compared with human milk feeding ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants

Eczema ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes eczema ‐ childhood (incidence) compared with human milk feeding ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants

Food allergy ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes food allergy ‐ childhood (incidence) compared with human milk feeding ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants

Cow's milk allergy ‐ infancy (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes cow's milk allergy ‐ infancy (incidence) compared with human milk feeding ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants

Cow's milk allergy ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes cow's milk allergy ‐ childhood (incidence) compared with human milk feeding ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs cow's milk formula

All allergic disease ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes all allergic disease ‐ childhood (incidence) compared with cow's milk formula ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs cow's milk formula

Asthma ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes asthma ‐ childhood (incidence) compared with cow's milk formula ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs cow's milk formula

Eczema ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes eczema ‐ childhood (incidence) compared with cow's milk formula ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Mortality: all cancers · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes cancer mortality risk No. of participants: 183,863 (7 observational… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Colorectal cancer risk (16 studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes colorectal cancer risk No. of participants: 712,746 (6 observational… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Lung cancer risk (17 studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes lung cancer risk No. of participants: 371,067 (11 observational… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Breast cancer risk (14 studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes breast cancer risk (women) No. of participants: 169,028 (8… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Bladder cancer risk No. of participants: 279,100 (5 observational studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes bladder cancer risk No. of participants: 279,100 (5 observational… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Prostate cancer risk (13 studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes prostate cancer risk No. of participants: 576,667 (21 observational… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review