Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,410 questions · 8,901 findings · 1,091 reviews

No studies found 1,687 · 19%GRADE not reported 1,469 · 16.5%Very low 1,969 · 22.1%Low 2,060 · 23.1%Moderate 1,302 · 14.6%High 414 · 4.7%

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Clinical examination with 24-month recall vs Clinical examination with 12-month recall

Caries increment in permanent teeth · Regular-attending primary-care dental patients aged 3, 16 or 18 years at entry (aged up to 20; low caries risk)

It is very uncertain whether clinical examination with 24-month recall changes dental caries: DMFS increment (permanent teeth) compared with clinical examination with 12-month recall (very low certainty).

1 finding from 1 review

Clobetasol propionate ointment vs Low-level laser therapy (LLLT)

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether clobetasol propionate ointment changes clinical resolution compared with low-level laser therapy (LLLT) (very low certainty).

1 finding from 1 review

Mechanical (high-volume) irrigation vs Manual (low-volume) irrigation

Presence of dry socket · Adults with mandibular third molars requiring removal

It is very uncertain whether mechanical (high-volume) irrigation changes alveolar osteitis compared with manual (low-volume) irrigation (very low certainty).

1 finding from 1 review

High-volume evacuation (HVE) vs Conventional dental suction (low-volume evacuator / saliva ejector)

Reduction in level of contamination in aerosols (CFU) during ultrasonic scaling at 150 cm from mouth · People undergoing aerosol-generating procedures (AGPs) in a dental setting

It is very uncertain whether high-volume evacuation (HVE) changes reduction in level of contamination in aerosols (CFU) during… compared with conventional dental suction (low-volume evacuator / saliva ejector) (very low certainty).

1 finding from 1 review

Higher JIA disease activity/severity (e.g., high JADAS/activity scores, polyarticular RF-negative subtype, active disease, anti-TNFalpha or cyclosporine medication) vs Lower JIA disease activity / inactive or milder JIA

Prevalence and severity of oral and TMJ diseases/conditions (periodontal status and dental caries) · Children and adolescents with juvenile idiopathic arthritis (JIA)

Some studies suggested greater JIA disease activity/severity (and certain medications) was associated with worse periodontal and caries outcomes, but small samples meant no solid conclusion could be drawn (ungraded).

1 finding from 1 review

Fluoride toothpaste vs Placebo (non-fluoride) toothpaste or fluoride toothpaste of a different concentration

Adverse effects of toothpaste · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1 finding from 1 review

Mid‐dose mifepristone (25 mg‐50 mg) vs low‐dose mifepristone (< 25 mg)

Specific side effects ‐ spotting/bleeding after treatment · women seeking emergency contraception

Mid‐dose mifepristone (25 mg‐50 mg) leads to higher specific side effects ‐ spotting/bleeding after treatment compared with low‐dose mifepristone (< 25 mg) (high certainty).

1 finding from 1 review

Constraint induced movement therapy (CIMT) vs low‐dose comparison

Unimanual capacity · children with unilateral cerebral palsy
2 findings from 1 review