Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,092 questions · 3,199 findings · 339 reviews · Headline outcomes only

No studies found 714 · 22.3%GRADE not reported 181 · 5.7%Very low 695 · 21.7%Low 908 · 28.4%Moderate 568 · 17.8%High 133 · 4.2%

ORS ≤ 270 mOsm/L (rice‐based) vs ORS ≥ 310 mOsm/L (glucose‐based)

Severe biochemical hyponatraemia (serum sodium < 125 mmol/L) · patients with cholera

ORS ≤ 270 mOsm/L (rice‐based) showed no clear difference in severe biochemical hyponatraemia(serum sodium < 125 mmol/L) compared with ORS ≥ 310 mOsm/L (glucose‐based) (low certainty).

1 finding from 1 review

ORS ≤ 270 mOsm/L (rice‐based) vs ORS ≥ 310 mOsm/L (glucose‐based)

Hyponatraemia (< 130 mmol/L) · patients with cholera

ORS ≤ 270 mOsm/L (rice‐based) showed no clear difference in biochemical hyponatraemia(serum sodium < 130 mmol/L) compared with ORS ≥ 310 mOsm/L (glucose‐based) (low certainty).

1 finding from 1 review

ORS ≤ 270 mOsm/L (glucose‐based) vs ORS ≥ 310 mOsm/L (glucose‐based)

Need for unscheduled intravenous infusion · patients with cholera

ORS ≤ 270 mOsm/L (glucose‐based) showed no clear difference in need for unscheduled intravenous infusion compared with ORS ≥ 310 mOsm/L (glucose‐based) (moderate certainty).

1 finding from 1 review

ORS ≤ 270 mOsm/L (glucose‐based) vs ORS ≥ 310 mOsm/L (glucose‐based)

Hyponatraemia (< 130 mmol/L) · patients with cholera

ORS ≤ 270 mOsm/L (glucose‐based) probably leads to higher biochemical hyponatraemia (serum sodium < 130 mmol/L) compared with ORS ≥ 310 mOsm/L (glucose‐based) (moderate certainty).

1 finding from 1 review

ORS ≤ 270 mOsm/L (glucose‐based) vs ORS ≥ 310 mOsm/L (glucose‐based)

Severe biochemical hyponatraemia (serum sodium < 125 mmol/L) · patients with cholera

ORS ≤ 270 mOsm/L (glucose‐based) showed no clear difference in severe biochemical hyponatraemia (serum sodium < 125 mmol/L) compared with ORS ≥ 310 mOsm/L (glucose‐based) (low certainty).

1 finding from 1 review