Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,771 questions · 10,185 findings · 893 reviews

No studies found 2,109 · 20.7%GRADE not reported 1,125 · 11%Very low 2,279 · 22.4%Low 2,514 · 24.7%Moderate 1,709 · 16.8%High 449 · 4.4%

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Intervention not reported

RT 40 (4 RCTs; 930 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

The intervention showed no clear difference in RT 40 (4 RCTs; 930 participants) (low certainty).

1 finding from 1 review

Intervention not reported

BEV_RT (1 RCT; 75 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

It is very uncertain whether the intervention changes BEV_RT (1 RCT; 75 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

TMZ (3 RCTs, 538 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

It is very uncertain whether the intervention changes TMZ (3 RCTs, 538 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

CRT (2 RCTs; 635 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

The intervention may leads to lower CRT (2 RCTs; 635 participants) (low certainty).

1 finding from 1 review

Intervention not reported

BEV_CRT (1 RCT; 73 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

The intervention led to lower BEV_CRT (1 RCT; 73 participants); GRADE not reported.

1 finding from 1 review

Intervention not reported

RT60 (5 RCTs; 713 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…

The intervention probably leads to lower RT60 (5 RCTs; 713 participants) (moderate certainty).

1 finding from 1 review

Intervention not reported

BEV_RT (1 RCT; 75 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…

The intervention showed no clear difference in BEV_RT (1 RCT; 75 participants); GRADE not reported.

1 finding from 1 review

Intervention not reported

RT40 (4 RCTs; 930 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…

The intervention may leads to lower RT40 (4 RCTs; 930 participants) (low certainty).

1 finding from 1 review

Intervention not reported

TMZ (3 RCTs, 538 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…

The intervention may leads to lower TMZ (3 RCTs, 538 participants) (low certainty).

1 finding from 1 review

Intervention not reported

CRT (2 RCTs; 635 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…

The intervention led to lower CRT (2 RCTs; 635 participants); GRADE not reported.

1 finding from 1 review

Intervention not reported

BEV_CRT (1 RCT; 73 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…

The intervention led to lower BEV_CRT (1 RCT; 73 participants); GRADE not reported.

1 finding from 1 review

Intervention not reported

BEV_RT (1 RCT; 75 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus bevacizumab (BEV_CRT);…

The intervention showed no clear difference in BEV_RT (1 RCT; 75 participants) (low certainty).

1 finding from 1 review

Clobetasol propionate ointment vs Low-level laser therapy (LLLT)

Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether clobetasol propionate ointment changes pain (mean score) compared with low-level laser therapy (LLLT) (very low certainty).

1 finding from 1 review

Clobetasol propionate ointment vs Low-level laser therapy (LLLT)

Clinical score · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether clobetasol propionate ointment changes clinical score compared with low-level laser therapy (LLLT) (very low certainty).

1 finding from 1 review

Topical triamcinolone acetonide vs Photodynamic therapy

Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical triamcinolone acetonide changes pain (mean score) compared with photodynamic therapy (very low certainty).

1 finding from 1 review

Clobetasol propionate ointment vs Low-level laser therapy (LLLT)

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether clobetasol propionate ointment changes clinical resolution compared with low-level laser therapy (LLLT) (very low certainty).

1 finding from 1 review

BoNT‐A vs usual care or physiotherapy

Instrumented gait analysis (kinematics) (not measured) · children with CP

The review found no eligible studies for this question.

3 findings from 1 review

BoNT‐A vs usual care or physiotherapy

Function · children with CP
3 findings from 1 review