Findings

What do systematic reviews say?

4,320 questions · 4,561 findings · 388 reviews

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No studies found 1,138 · 25%GRADE not reported 886 · 19.4%Very low 1,014 · 22.2%Low 849 · 18.6%Moderate 543 · 11.9%High 131 · 2.9%

HALOPERIDOL vs placebo

The event rate of intensive care delirium within 28 days. · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

Haloperidol showed no clear difference in the event rate of intensive care delirium within 28 days. compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
RR 1.01 [0.87, 1.17]
1 study · 1439 participants
Moderate

HALOPERIDOL vs placebo

In‐hospital mortality within 28 days. · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

Haloperidol showed no clear difference in in‐hospital mortality within 28 days. compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
RR 0.98 [0.8, 1.22]
2 studies · 1580 participants
Moderate

Number of delirium ‐ and coma‐free days (within 28 days) measured by CAM‐ICU or ICDSC · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

1 finding from 1 review

Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1580 participants
Moderate

HALOPERIDOL vs placebo

Ventilator‐free days up to day 28 · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

1 finding from 1 review

Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1439 participants
High

HALOPERIDOL vs placebo

Duration of ICU stay · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

1 finding from 1 review

Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1580 participants
High

HALOPERIDOL vs placebo

Cognitive impairment · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HALOPERIDOL vs placebo

Adverse events · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

1 finding from 1 review

Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1580 participants
Moderate

Intervention not reported

Tobacco use · children and young people aged 0 to 18 years

The intervention showed no clear difference in tobacco use (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 1.28 [0.75, 2.19]
2 studies · 521 participants
Moderate

Intervention not reported

Alcohol use · children and young people aged 0 to 18 years

The intervention showed no clear difference in alcohol use (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 0.8 [0.58, 1.11]
4 studies · 1911 participants
Moderate

Intervention not reported

Cannabis use · children and young people aged 0 to 18 years

The intervention showed no clear difference in cannabis use (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 0.69 [0.46, 1.04]
2 studies · 362 participants
Moderate

Intervention not reported

Illicit drug use · children and young people aged 0 to 18 years

The review found no eligible studies for this question.

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Antisocial behaviour · children and young people aged 0 to 18 years

The intervention showed no clear difference in antisocial behaviour (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 1.02 [0.62, 1.69]
1 study · 200 participants
Moderate

Intervention not reported

Sexual risk behaviour · children and young people aged 0 to 18 years

The intervention showed no clear difference in sexual risk behaviour (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 0.42 [0.14, 1.25]
1 study · 162 participants
Moderate

Intervention not reported

Physical activity · children and young people aged 0 to 18 years

The intervention showed no clear difference in physical activity (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 1.11 [0.74, 1.67]
2 studies · 1530 participants
Moderate

Intervention not reported

Tobacco use · children and young people aged 0 to 18 years

The intervention showed no clear difference in tobacco use (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 0.78 [0.4, 1.53]
2 studies · 313 participants
Moderate

Intervention not reported

Alcohol use · children and young people aged 0 to 18 years

The intervention showed no clear difference in alcohol use (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 0.83 [0.47, 1.46]
3 studies · 417 participants
Moderate

Intervention not reported

Cannabis use · children and young people aged 0 to 18 years

The intervention showed no clear difference in cannabis use (low certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 1.02 [0.52, 2.02]
3 studies · 380 participants
Low

Intervention not reported

Illicit drug use · children and young people aged 0 to 18 years

The intervention showed no clear difference in illicit drug use (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 0.74 [0.42, 1.31]
1 study · 69 participants
Moderate

Intervention not reported

Alcohol use · children and young people aged 0 to 18 years

The intervention showed no clear difference in alcohol use (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 1.02 [0.8, 1.31]
4 studies · 1204 participants
Moderate

Intervention not reported

Antisocial behaviour · children and young people aged 0 to 18 years

The intervention showed no clear difference in antisocial behaviour (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 0.84 [0.57, 1.24]
5 studies · 772 participants
Moderate