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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

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No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

Small‐for‐gestational age · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

The review found no eligible studies for this question.

1 finding from 1 review

Periodontal treatment (scaling and root planing, polishing, or surgery), alone or with oral hygiene counselling, antiseptics, or antimicrobials vs no treatment

Low birth weight (< 2.5 kg) · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

Periodontal treatment (scaling and root planing, polishing, or… may leads to lower birth weight (low birth weight < 2500 g) compared with no treatment (low certainty).

1 finding from 1 review

One type of adhesive used to bond molar tubes (chemically-cured composite, light-cured composite, conventional glass ionomer, poly-acid modified composite/compomer, or resin-modified glass ionomer) vs Any other type of adhesive used to bond molar tubes

Decalcification (presence or absence of decay around the attachment) · Participants with full arch fixed orthodontic appliance(s) with molar tubes bonded to first or second permanent molars; excludes prior…

The review found no eligible studies for this question.

1 finding from 1 review

Amifostine vs no treatment/placebo

Salivary flow rate (stimulated) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review

Glass ionomer-based sealant vs Resin-based sealant

Dentine caries in permanent molars (24 months) · Children and adolescents (general population, aged under 20 years)
1 finding from 1 review

Antimicrobial lozenge vs placebo

Side effects (other: dryness in mouth, diarrhoea, constipation) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review

Pilocarpine vs no treatment/placebo

Speech difficulties (VAS 0-100 mm) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

Pilocarpine led to higher speech difficulties (VAS 0-100 mm) compared with no treatment/placebo; GRADE not reported.

1 finding from 1 review

High-viscosity glass-ionomer ART restorations vs Conventional treatment using H-GIC (rotary instruments)

Restoration failure (primary dentition) · People with dental caries in primary teeth (mainly children)

ART using high-viscosity glass ionomer cement (H-GIC), hand… may leads to higher restoration failure (primary dentition) compared with conventional treatment using H-GIC (rotary instruments) (low certainty).

1 finding from 1 review

Periodontal treatment (scaling and root planing, polishing, or surgery), alone or with oral hygiene counselling, antiseptics, or antimicrobials vs no treatment

Maternal death · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination
1 finding from 1 review

G‐CSF vs placebo or no treatment

Normalcy of diet (percutaneous endoscopic gastrostomy) · Adults with cancer receiving treatment

Granulocyte-colony stimulating factor (G-CSF) showed no clear difference in normalcy of diet (percutaneous endoscopic gastrostomy) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Amifostine vs no treatment/placebo

Salivary flow rate · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

Amifostine led to higher salivary flow rate (incidence of > 0.1 g saliva/5 min, unstimulated) compared with no treatment/placebo; GRADE not reported.

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Normalcy of diet (total parenteral nutrition) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in normalcy of diet (total parenteral nutrition) compared with placebo; GRADE not reported.

1 finding from 1 review

Acupuncture vs sham control

Health‐related quality of life · Patients with idiopathic dysgeusia and hypogeusia
1 finding from 1 review
  • Interventions for managing taste disturbances 2017 · Cochrane All outcomes
    Results (health-related quality of life): Brandt 2008 assessed HRQoL in dysgeusia patients and reported significant improvement in psychological symptoms in the acupuncture group and increased quality of life in both…
    1 study
    GRADE not reported

Amifostine 200 mg/m2 three times weekly vs Amifostine 200 mg/m2 five times weekly

Vomiting · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

Amifostine 200 mg/m2 three times weekly showed no clear difference in vomiting (adverse effect) compared with amifostine 200 mg/m2 five times weekly; GRADE not reported.

1 finding from 1 review