Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,756 questions · 13,493 findings · 1,305 reviews · Headline outcomes only

No studies found 2,594 · 19.2%GRADE not reported 728 · 5.4%Very low 2,868 · 21.3%Low 3,777 · 28%Moderate 2,620 · 19.4%High 906 · 6.7%

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Topical plus systemic prophylaxis vs placebo or no treatment

Respiratory infections · adults receiving mechanical ventilation for at least 48 hours

Topical plus systemic prophylaxis probably leads to lower respiratory tract infections compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Topical plus systemic prophylaxis vs placebo or no treatment

Dropouts due to adverse events · adults receiving mechanical ventilation for at least 48 hours

Topical plus systemic prophylaxis showed no clear difference in dropouts due to adverse events compared with placebo or no treatment (low certainty).

1 finding from 1 review

Topical plus systemic prophylaxis vs placebo or no treatment

Gastrointestinal adverse events · adults receiving mechanical ventilation for at least 48 hours

Topical plus systemic prophylaxis showed no clear difference in gastrointestinal adverse events compared with placebo or no treatment (low certainty).

1 finding from 1 review

Topical plus systemic prophylaxis vs placebo or no treatment

Allergic adverse events · adults receiving mechanical ventilation for at least 48 hours

Topical plus systemic prophylaxis showed no clear difference in allergic adverse events compared with placebo or no treatment (low certainty).

1 finding from 1 review

Albendazole vs placebo or no anthelmintics

Seizure recurrence ‐ participants with a single cyst · people with neurocysticercosis

Albendazole probably leads to lower seizure recurrence ‐ participants with a single cyst compared with placebo or no anthelmintics (moderate certainty).

1 finding from 1 review

Albendazole vs placebo or no anthelmintics

Seizure recurrence ‐ participants with multiple (> 1) cysts · people with neurocysticercosis

It is very uncertain whether albendazole changes seizure recurrence ‐ participants with multiple (> 1) cysts compared with placebo or no anthelmintics (very low certainty).

1 finding from 1 review