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Evidence found and GRADE certainty

1,270 questions · 1,480 findings · 174 reviews

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No studies found 252 · 17%GRADE not reported 405 · 27.4%Very low 301 · 20.3%Low 284 · 19.2%Moderate 174 · 11.8%High 64 · 4.3%

Single-surface ART restoration using high-viscosity glass ionomer vs Multi-surface ART with high-viscosity GIC

Restoration failure · Children (2-9 years) with caries in posterior primary teeth

Single-surface ART restorations had a low reported mean annual failure rate (about 5%; ungraded).

1 finding from 1 review

Single-surface ART restoration using high-viscosity glass ionomer vs Multi-surface ART with high-viscosity GIC

Restoration survival · Children with decayed primary molar teeth

Single-surface ART/HVGIC restorations had high reported survival (86% at 3 years), significantly higher than multi-surface restorations (ungraded).

1 finding from 1 review

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with artemisinin partner,

Participants with severe haemolysis · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.4 to 0.5 mg/kg showed no clear difference in participants with severe haemolysis compared with no primaquine, with artemisinin partner, (low certainty).

1 finding from 1 review

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with non‐artemisinin partner,

Participants with gametocytes at day 4‐5, by microscopy · adults and children with malaria being treated with non‐artemisinin treatment

Single dose primaquine at 0.4 to 0.5 mg/kg showed no clear difference in participants with gametocytes at day 4‐5, by microscopy compared with no primaquine, with non‐artemisinin partner, (moderate certainty).

1 finding from 1 review

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with non‐artemisinin partner,

Participants with gametocytes at day 8, by microscopy · adults and children with malaria being treated with non‐artemisinin treatment

Single dose primaquine at 0.4 to 0.5 mg/kg probably leads to lower participants with gametocytes at day 8, by microscopy compared with no primaquine, with non‐artemisinin partner, (moderate certainty).

1 finding from 1 review

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with artemisinin partner,

Participants infectious at day 8 · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.4 to 0.5 mg/kg may leads to lower participants infectious at day 3‐4 compared with no primaquine, with artemisinin partner, (low certainty).

2 findings from 1 review

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with artemisinin partner,

Participants with gametocytes at day 3‐4, by PCR · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.4 to 0.5 mg/kg showed no clear difference in participants with gametocytes at day 3‐4, by PCR compared with no primaquine, with artemisinin partner, (moderate certainty).

1 finding from 1 review

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with artemisinin partner,

Participants with gametocytes at day 8, by PCR · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.4 to 0.5 mg/kg leads to lower participants with gametocytes at day 8, by PCR compared with no primaquine, with artemisinin partner, (high certainty).

1 finding from 1 review

Class-I (single-surface) cavity restoration vs Class-II (proximal/multi-surface) cavity restoration

Treatment failure (annual failure rate) by cavity class · Children with carious primary teeth restored in Class-I versus Class-II cavities, no pulp therapy

Class-II restorations failed more than Class-I (annual failure 5-28.9% vs 1.2-14.7% in ART studies); low quality of evidence (ungraded).

1 finding from 1 review

Single dose primaquine at 0.2 to 0.25 mg/kg vs no primaquine, with artemisinin partner,

Participants infectious at day 8 · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.2 to 0.25 mg/kg may leads to lower participants infectious at day 3‐4 compared with no primaquine, with artemisinin partner, (low certainty).

2 findings from 1 review

Single dose primaquine at 0.2 to 0.25 mg/kg vs no primaquine, with artemisinin partner,

Participants with gametocytes at day 3‐4, by PCR · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.2 to 0.25 mg/kg showed no clear difference in participants with gametocytes at day 3 to 4 by PCR compared with no primaquine, with artemisinin partner, (moderate certainty).

1 finding from 1 review

Single dose primaquine at 0.2 to 0.25 mg/kg vs no primaquine, with artemisinin partner,

Participants with gametocytes at day 8, by PCR · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.2 to 0.25 mg/kg leads to lower participants with gametocytes at day 8 by PCR compared with no primaquine, with artemisinin partner, (high certainty).

1 finding from 1 review

Single dose primaquine at 0.2 to 0.25 mg/kg vs no primaquine, with artemisinin partner,

Participants with severe haemolysis · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.2 to 0.25 mg/kg showed no clear difference in participants with severe haemolysis compared with no primaquine, with artemisinin partner, (moderate certainty).

1 finding from 1 review

No intervention (single-arm cohort estimates) vs No comparator

First dentine caries incidence rate per person-year at risk (D3) · Caries-free children and adolescents with permanent dentition

Sánchez-Pérez et al. 2010 reported an incidence rate of 0.07 per person-year at risk.

16 findings from 1 review
Show 13 more findings

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Cumulative live birth · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Repeated single embryo transfer (mixed policies) showed no clear difference in cumulative live birth compared with multiple embryo transfer (low certainty).

1 finding from 1 review

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Multiple pregnancy · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Repeated single embryo transfer (mixed policies) probably leads to lower multiple pregnancy compared with multiple embryo transfer (moderate certainty).

1 finding from 1 review