Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

508 questions · 529 findings · 58 reviews

No studies found 191 · 36.1%GRADE not reported 49 · 9.3%Very low 143 · 27%Low 92 · 17.4%Moderate 51 · 9.6%High 3 · 0.6%

Dornase alfa vs hypertonic saline

Mean relative percentage in FVC (L) at 3 months · children with cystic fibrosis

Dornase alfa showed no clear difference in mean relative percentage in FVC (L) at 3 months compared with hypertonic saline (low certainty).

1 finding from 1 review

Dornase alfa vs hypertonic saline

Mean relative percentage in quality of life score at 3 months · children with cystic fibrosis

Dornase alfa showed no clear difference in mean relative percentage in quality of life score at 3 months compared with hypertonic saline (low certainty).

1 finding from 1 review

Gemcitabine vs Normal saline

Overall survival (absolute effect size estimates based on survival rate at 12 months) · patients with non‐muscle invasive bladder cancer

It is very uncertain whether gemcitabine changes time to death from any cause (absolute effect size estimates based… compared with saline (very low certainty).

1 finding from 1 review