Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,747 questions · 3,943 findings · 594 reviews

No studies found 784 · 19.9%GRADE not reported 530 · 13.4%Very low 1,040 · 26.4%Low 981 · 24.9%Moderate 444 · 11.3%High 164 · 4.2%

Summary of findings: Energy‐restricted diet vs no energy‐restricted diet (maternal outcomes)

Large‐for‐gestational age · pregnant women with GDM

Summary of findings: Energy‐restricted diet showed no clear difference in large‐for‐gestational age compared with no energy‐restricted diet (neonatal/child/adulthood outcomes) (low certainty).

1 finding from 1 review

Summary of findings: Energy‐restricted diet vs no energy‐restricted diet (maternal outcomes)

Neonatal hypoglycaemia · pregnant women with GDM

It is very uncertain whether summary of findings: Energy‐restricted diet changes neonatal hypoglycaemia compared with no energy‐restricted diet (neonatal/child/adulthood outcomes) (very low certainty).

1 finding from 1 review

Ferric sulphate (FS) + mineral trioxide aggregate (MTA) vs Ferric sulphate (FS)

Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
  • Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
    mean 22 months
    Assessed pain, soft tissue, mobility, adjacent tissue inflammation, radiolucency, root resorption, pulp canal obliteration (Doyle 2010); no clinical/radiological failure outcome; no significant differences
    1 study · 135 participants
    GRADE not reported

Fluoride-free nano-/micro-hydroxyapatite (nHA) dentifrice vs Control (regular fluoride) dentifrice

Caries lesion initiation/progression (ICDAS score, laser fluorescence/DIAGNOdent, photographic pixels, enamel acid resistance) · Patients (children and adults, age 3-40 years) with initial enamel caries lesions (non-orthodontic and orthodontic)

No meta-analysis was possible for the 5 in vivo RCTs (high heterogeneity); narratively nHA showed generally no significant difference versus fluoridated dentifrice, and the evidence was not graded (ungraded).

1 finding from 1 review
  • Efficacy of nano-hydroxyapatite on caries prevention-a systematic review and meta-analysis. 2022 All outcomes
    Median follow-up 6 months (range 6-12 months) · In vivo (clinical); non-orthodontic and orthodontic patients
    No meta-analysis was performed for the in vivo studies owing to high heterogeneity (population, control group, outcomes, follow-up periods, risk of bias) and differing statistical designs (e.g., non-inferiority);…
    5 studies · 420 participants
    GRADE not reported