Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

749 questions · 769 findings · 63 reviews · Headline outcomes only

No studies found 202 · 26.3%GRADE not reported 31 · 4%Very low 172 · 22.4%Low 211 · 27.4%Moderate 106 · 13.8%High 47 · 6.1%

28 days on/off antibiotic regimen vs 28 days on/off placebo regimen

Exacerbation frequency · people with bronchiectasis

28 days on/off antibiotic regimen showed no clear difference in exacerbation frequency compared with 28 days on/off placebo regimen (high certainty).

2 findings from 1 review