What do systematic reviews say?

Oral antibiotics vs placebo

• Oral antibiotics for chronic blepharitis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 93 participants
  Very low

Oral antibiotics vs placebo

• Oral antibiotics for chronic blepharitis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 93 participants
  Very low

Oral antibiotics vs placebo

It is very uncertain whether oral antibiotics changes adverse events at 1 month compared with placebo (very low certainty).

• Oral antibiotics for chronic blepharitis 2021 · Cochrane Headline outcomes only
  RR 6.13 [1.94, 19.41]
  1 study · 93 participants
  Very low

Oral antibiotics vs placebo

The review found no eligible studies for this question.

• Oral antibiotics for chronic blepharitis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral antibiotics vs placebo

The review found no eligible studies for this question.

• Oral antibiotics for chronic blepharitis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral misoprostol vs placebo/no treatment

The review found no eligible studies for this question.

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral misoprostol vs vaginal dinoprostone

Oral misoprostol may leads to lower uterine hyperstimulation with fetal heart rate changes compared with vaginal dinoprostone (low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 0.49 [0.4, 0.59]
  11 studies · 9084 participants
  Low

Oral misoprostol vs vaginal dinoprostone

It is very uncertain whether oral misoprostol changes oxytocin augmentation compared with vaginal dinoprostone (very low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 0.9 [0.75, 1.09]
  12 studies · 9451 participants
  Very low

Oral misoprostol vs vaginal dinoprostone

Oral misoprostol probably leads to lower uterine hyperstimulation without fetal heart rate changes compared with vaginal dinoprostone (moderate certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 0.83 [0.72, 0.97]
  9 studies · 8171 participants
  Moderate

Oral misoprostol vs vaginal dinoprostone

Oral misoprostol showed no clear difference in apgar score less than seven at five minutes compared with vaginal dinoprostone (low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 0.8 [0.52, 1.23]
  12 studies · 9473 participants
  Low

Oral misoprostol vs vaginal dinoprostone

Oral misoprostol showed no clear difference in admission to neonatal intensive care unit compared with vaginal dinoprostone (low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 0.8 [0.6, 1.07]
  11 studies · 9278 participants
  Low

Oral misoprostol vs vaginal misoprostol

Oral misoprostol may leads to lower vaginal birth within 24 hours compared with vaginal misoprostol (low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 0.81 [0.68, 0.95]
  16 studies · 3451 participants
  Low

Oral misoprostol vs vaginal misoprostol

Oral misoprostol showed no clear difference in caesarean section compared with vaginal misoprostol (low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 1 [0.86, 1.16]
  32 studies · 5914 participants
  Low

Oral misoprostol vs vaginal misoprostol

Oral misoprostol may leads to lower uterine hyperstimulation with fetal heart rate changes compared with vaginal misoprostol (low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 0.69 [0.53, 0.92]
  25 studies · 4857 participants
  Low

Oral misoprostol vs vaginal misoprostol

Oral misoprostol may leads to higher oxytocin augmentation compared with vaginal misoprostol (low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 1.28 [1.15, 1.44]
  28 studies · 5416 participants
  Low

Oral misoprostol vs vaginal misoprostol

Oral misoprostol may leads to lower uterine hyperstimulation without fetal heart rate changes compared with vaginal misoprostol (low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 0.69 [0.49, 0.99]
  16 studies · 3212 participants
  Low

Oral misoprostol vs placebo/no treatment

Oral misoprostol showed no clear difference in caesarean section compared with placebo/no treatment (low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 0.81 [0.59, 1.11]
  4 studies · 594 participants
  Low

Oral misoprostol vs vaginal misoprostol

Oral misoprostol showed no clear difference in apgar score less than seven at five minutes compared with vaginal misoprostol (low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 0.68 [0.46, 1.02]
  21 studies · 4438 participants
  Low

Oral misoprostol vs vaginal misoprostol

Oral misoprostol showed no clear difference in admission to neonatal intensive care unit compared with vaginal misoprostol (moderate certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 1.03 [0.86, 1.23]
  23 studies · 4450 participants
  Moderate

Oral misoprostol vs intravenous (IV) oxytocin

Oral misoprostol showed no clear difference in vaginal birth within 24 hours compared with intravenous oxytocin (low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 1.12 [0.95, 1.33]
  3 studies · 466 participants
  Low