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What do systematic reviews say?

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Evidence found and GRADE certainty

1,773 questions · 1,817 findings · 212 reviews · Headline outcomes only

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No studies found 383 · 21.1%GRADE not reported 192 · 10.6%Very low 472 · 26%Low 444 · 24.4%Moderate 228 · 12.5%High 98 · 5.4%

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Parental self‐harm ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Parent–child relationship ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Parenting skills; postintervention · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Different types of pressure garment (Caroskin Tricot plus an adhesive silicone gel sheet vs Gecko Nanoplast

Scar improvement (POSAS) (0–10, higher score = more severe scarring) · people with burn wounds likely to develop hypertrophic scarring

The review found no eligible studies for this question.

2 findings from 1 review

Self‐directed stress management (it is unclear whether these interventions replaced standard treatment or were added to standard treatment) vs usual care

Treatment success as defined by the authors · people with Crohn's disease

The review found no eligible studies for this question.

1 finding from 1 review

Self‐directed stress management (it is unclear whether these interventions replaced standard treatment or were added to standard treatment) vs usual care

Pain frequency or change in pain frequency · people with Crohn's disease

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin C 1400 mg plus vitamin E 800 mg vs placebo

Acute chest syndrome ( · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)

It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes frequency of sickle cell‐related complications: acute chest syndrome compared with placebo (very low certainty).

1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Adverse events: all ‐ other events ‐ not listed above (e.g. dysuria, neck pain, eye discomfort) (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological intervention and non‐invasive brain stimulation… changes adverse events: all ‐ other events ‐ not listed above (e.g.… compared with a pharmacological intervention and sham stimulation or usual care… (very low certainty).

1 finding from 1 review