Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

335 questions · 406 findings · 23 reviews

No studies found 93 · 22.9%GRADE not reported 166 · 40.9%Very low 66 · 16.3%Low 65 · 16%Moderate 14 · 3.4%High 2 · 0.5%

Chlorhexidine varnish vs placebo or no treatment

Adverse events (e.g. ulcers, tooth staining) · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…
1 finding from 1 review

Chlorhexidine mouthrinse vs Placebo or no intervention (including routine care)

Outcome not reported · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine gel (0.12%) vs no treatment

Pain, quality of life, patient satisfaction or costs · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine spray vs Placebo or no intervention (including routine care)

Outcome not reported · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine toothpaste vs Placebo or no intervention (including routine care)

Outcome not reported · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine varnish vs placebo or no treatment

Pain, quality of life, patient satisfaction or costs · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine chewing gum vs Placebo or no intervention (including routine care)

Outcome not reported · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

The review found no eligible studies for this question.

1 finding from 1 review

Autopolymerised sealant vs Light polymerised sealant

Retention of sealant (complete or partial retention) · Children with sound primary molars, aged 2-4 years (municipal dental clinics or hospital paediatric clinics, Denmark)

It is very uncertain whether autopolymerised sealant changes retention of sealant (complete or partial retention) compared with light polymerised sealant (very low certainty).

1 finding from 1 review

Glass ionomer-based sealant vs Resin-based sealant

Adverse events · 'Healthy' children with caries-free second primary molars, aged 3-5 years (schools and kindergartens, India and China)
1 finding from 1 review
  • 1 study reported adverse events as some discomfort such as nausea; 1 child experienced a strong gag reflex following the glass ionomer-based sealant while 8 children reported feeling uncomfortable after the fluoride…
    1 study · 100 participants
    Very low

Cessation of water fluoridation (fluoride removed from the water supply) vs Continued fluoridated water

Adverse effects · People of all ages in a previously fluoridated community (Maupome 2001: children with generally low caries experience)

The review found no eligible studies for this question.

1 finding from 1 review

Silver diamine fluoride (SDF) vs Sealants or resin infiltration

Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review

SDF (given at a particular frequency, concentration, or duration) vs SDF (given at a different frequency, concentration, or duration)

Aesthetics · Children and adults (with or without carious lesions)
1 finding from 1 review

Silver diamine fluoride (SDF) vs Restoration (restorative treatment)

Aesthetics · Children and adults (with or without carious lesions)
1 finding from 1 review

Silver diamine fluoride (SDF) vs Glass ionomer cement (GIC) plus fluoride varnish

Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review