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Evidence found and GRADE certainty

341 questions · 354 findings · 26 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

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No studies found 58 · 16.4%GRADE not reported 4 · 1.1%Very low 51 · 14.4%Low 133 · 37.6%Moderate 82 · 23.2%High 26 · 7.3%

EGFR tyrosine kinase inhibitor (TKI) vs observation

Progression‐free survival · maintenance treatment of epithelial ovarian cancer after first‐line chemotherapy

It is very uncertain whether EGFR tyrosine kinase inhibitor (TKI) changes progression‐free survival compared with observation alone (very low certainty).

1 finding from 1 review

Hysterectomy (simple or radical) with radiotherapy vs Radiotherapy alone

Progression‐free survival (PSF) · women with locally advanced cervical cancer

Hysterectomy (simple or radical) with radiotherapy showed no clear difference in progression‐free survival Median compared with radiotherapy alone (low certainty).

1 finding from 1 review

Hysterectomy (simple or radical) with chemoradiotherapy vs chemoradiotherapy alone

Death (all causes) · women with locally advanced cervical cancer

It is very uncertain whether hysterectomy (simple or radical) with chemoradiotherapy changes overall survival Median compared with chemoradiotherapy alone (very low certainty).

1 finding from 1 review

Hysterectomy (simple or radical) with chemoradiotherapy vs chemoradiotherapy alone

Progression or event‐free survival Median · women with locally advanced cervical cancer

It is very uncertain whether hysterectomy (simple or radical) with chemoradiotherapy changes progression or event‐free survival Median compared with chemoradiotherapy alone (very low certainty).

1 finding from 1 review

Hysterectomy (simple or radical) with chemoradiotherapy vs internal radiotherapy (brachytherapy) with chemoradiotherapy

Death (all causes) · women with locally advanced cervical cancer

Hysterectomy (simple or radical) with chemoradiotherapy showed no clear difference in overall survival Median compared with internal radiotherapy (brachytherapy) with chemoradiotherapy (low certainty).

1 finding from 1 review

Hysterectomy (simple or radical) with chemoradiotherapy vs internal radiotherapy (brachytherapy) with chemoradiotherapy

Progression or event‐free survival Median · women with locally advanced cervical cancer

Hysterectomy (simple or radical) with chemoradiotherapy showed no clear difference in progression or event‐free survival Median compared with internal radiotherapy (brachytherapy) with chemoradiotherapy (low certainty).

1 finding from 1 review

Hysterectomy (simple or radical) with chemoradiotherapy vs internal radiotherapy (brachytherapy) with chemoradiotherapy

Severe late complications · women with locally advanced cervical cancer

Hysterectomy (simple or radical) with chemoradiotherapy may leads to higher severe late complications compared with internal radiotherapy (brachytherapy) with chemoradiotherapy (low certainty).

1 finding from 1 review

Hysterectomy (simple or radical) with radiotherapy vs Radiotherapy alone

Death (all causes) · women with locally advanced cervical cancer

Hysterectomy (simple or radical) with radiotherapy showed no clear difference in overall survival Median compared with radiotherapy alone (low certainty).

1 finding from 1 review

Intervention not reported

Intervention: radiotherapy Comparison: no adjuvant treatment Outcome: neurocognitive impairment at 5‐ to 6‐year · people with glioma surviving at least two years

It is very uncertain whether the intervention changes intervention: radiotherapy Comparison: no adjuvant treatment… (very low certainty).

1 finding from 1 review

Intervention not reported

Intervention: radiotherapy Comparison: no adjuvant treatment Outcome: neurocognitive impairment at 12 year · people with glioma surviving at least two years

It is very uncertain whether the intervention changes intervention: radiotherapy Comparison: no adjuvant treatment… (very low certainty).

1 finding from 1 review

Intervention not reported

Intervention: radiotherapy Comparison: no adjuvant treatment Outcome: neurocognitive impairment at 2 year · people with glioma surviving at least two years

It is very uncertain whether the intervention changes intervention: radiotherapy Comparison: no adjuvant treatment… (very low certainty).

1 finding from 1 review

Intervention not reported

Intervention: high‐dose radiotherapy Comparison: low‐dose radiotherapy Outcome: neurocognitive impairment at 2 years after treatment · people with glioma surviving at least two years

It is very uncertain whether the intervention changes intervention: high‐dose radiotherapy Comparison: low‐dose… (very low certainty).

1 finding from 1 review