Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,954 questions · 2,335 findings · 149 reviews · All outcomes

No studies found 436 · 18.7%GRADE not reported 1,370 · 58.7%Very low 254 · 10.9%Low 173 · 7.4%Moderate 80 · 3.4%High 22 · 0.9%

Habit reversal vs waiting list control

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adults over 18 years of age with chronic orofacial pain (temporomandibular disorder (TMD))

Habit reversal led to lower pain intensity (short term / post-treatment) compared with waiting list control; GRADE not reported.

1 finding from 1 review

Flossing plus toothbrushing (self-performed; manual or automated floss) vs Toothbrushing alone

Bad breath (halitosis) · Dentate adults aged 16 years or older (excluding orthodontic patients and those with severe periodontal disease)

The review found no eligible studies for this question.

1 finding from 1 review

Psychosocial interventions (cognitive behavioural therapy, biofeedback, combination CBT/biofeedback, physical self-regulation/posture self-control) vs usual care

Depression (long term) · Adults over 18 years of age with chronic orofacial pain (temporomandibular disorder (TMD))

Psychosocial interventions (cognitive behavioural therapy,… led to lower depression (long term) compared with usual care (conservative treatment: education, counselling,…; GRADE not reported.

1 finding from 1 review

Flossing plus toothbrushing (self-performed; manual or automated floss) vs Toothbrushing alone

Calculus · Dentate adults aged 16 years or older (excluding orthodontic patients and those with severe periodontal disease)

The review found no eligible studies for this question.

1 finding from 1 review

Flossing plus toothbrushing (self-performed; manual or automated floss) vs Toothbrushing alone

Quality of life · Dentate adults aged 16 years or older (excluding orthodontic patients and those with severe periodontal disease)

The review found no eligible studies for this question.

1 finding from 1 review

Cognitive behaviour therapy vs Attention placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adults over 18 years of age with chronic orofacial pain (burning mouth syndrome)

Cognitive (behavioural) therapy led to lower burning mouth pain intensity (6-month follow-up) compared with attention placebo; GRADE not reported.

1 finding from 1 review

Cognitive behaviour therapy vs Attention placebo

Burning mouth pain intensity (post-treatment) · Adults over 18 years of age with chronic orofacial pain (burning mouth syndrome)

Cognitive (behavioural) therapy led to lower burning mouth pain intensity (post-treatment) compared with attention placebo; GRADE not reported.

1 finding from 1 review

Psychosocial interventions (cognitive behavioural therapy, biofeedback, combination CBT/biofeedback, physical self-regulation/posture self-control) vs usual care

Reduction in pain intensity · Adults over 18 years of age with chronic orofacial pain (temporomandibular disorder (TMD))

Psychosocial interventions (cognitive behavioural therapy,… led to higher pain intensity (short term) compared with usual care (conservative treatment: education, counselling,…; GRADE not reported.

1 finding from 1 review

Psychosocial interventions (cognitive behavioural therapy, biofeedback, combination CBT/biofeedback, physical self-regulation/posture self-control) vs usual care

Pain severity - impact: activity interference / disability (long term) · Adults over 18 years of age with chronic orofacial pain (temporomandibular disorder (TMD))

Psychosocial interventions (cognitive behavioural therapy,… led to lower pain severity - impact: activity interference / disability (long term) compared with usual care (conservative treatment: education, counselling,…; GRADE not reported.

1 finding from 1 review

Minimal incision palatopharyngoplasty (MIPP) vs MIPP with additional individualised velopharyngeal surgery (pharyngeal flap or sphincter pharyngoplasty)

Quality of life (validated questionnaire) · Children or adolescents aged 3 years or older with velopharyngeal insufficiency (VPI) associated with non-syndromic submucous cleft palate

The review found no eligible studies for this question.

1 finding from 1 review

Minimal incision palatopharyngoplasty (MIPP) vs MIPP with additional individualised velopharyngeal surgery (pharyngeal flap or sphincter pharyngoplasty)

Instrumental assessment: nasalance score (nasometry and pressure-flow measure) · Children or adolescents aged 3 years or older with velopharyngeal insufficiency (VPI) associated with non-syndromic submucous cleft palate

The review found no eligible studies for this question.

1 finding from 1 review

Minimal incision palatopharyngoplasty (MIPP) vs MIPP with additional individualised velopharyngeal surgery (pharyngeal flap or sphincter pharyngoplasty)

Self-esteem (Piers-Harris self-concept scale) · Children or adolescents aged 3 years or older with velopharyngeal insufficiency (VPI) associated with non-syndromic submucous cleft palate

The review found no eligible studies for this question.

1 finding from 1 review

Minimal incision palatopharyngoplasty (MIPP) vs MIPP with additional individualised velopharyngeal surgery (pharyngeal flap or sphincter pharyngoplasty)

Instrumental assessment: velopharyngeal complete closure and gap size (videonasopharyngoscopy and multiview videofluoroscopy) · Children or adolescents aged 3 years or older with velopharyngeal insufficiency (VPI) associated with non-syndromic submucous cleft palate
1 finding from 1 review
  • Interventions for the management of submucous cleft palate 2008 · Cochrane All outcomes
    3 months post-operatively
    Complete closure occurred in 32 (86%) of the participants in group 1 (MIPP) and in 31 (89%) in group 2, P > 0.05. After eliminating the nine patients with residual velopharyngeal insufficiency, the post-operative gap…
    1 study · 72 participants
    GRADE not reported

Minimal incision palatopharyngoplasty (MIPP) vs MIPP with additional individualised velopharyngeal surgery (pharyngeal flap or sphincter pharyngoplasty)

Adverse effect: failure of muscle fusion in the region of the cleft after surgery · Children or adolescents aged 3 years or older with velopharyngeal insufficiency (VPI) associated with non-syndromic submucous cleft palate
1 finding from 1 review

Minimal incision palatopharyngoplasty (MIPP) vs MIPP with additional individualised velopharyngeal surgery (pharyngeal flap or sphincter pharyngoplasty)

Adverse effect: unacceptable nasal resonance after repair · Children or adolescents aged 3 years or older with velopharyngeal insufficiency (VPI) associated with non-syndromic submucous cleft palate

The review found no eligible studies for this question.

1 finding from 1 review

Minimal incision palatopharyngoplasty (MIPP) vs MIPP with additional individualised velopharyngeal surgery (pharyngeal flap or sphincter pharyngoplasty)

Adverse effect: obstructive sleep apnoea or airway compromise · Children or adolescents aged 3 years or older with velopharyngeal insufficiency (VPI) associated with non-syndromic submucous cleft palate
1 finding from 1 review

Minimal incision palatopharyngoplasty (MIPP) vs MIPP with additional individualised velopharyngeal surgery (pharyngeal flap or sphincter pharyngoplasty)

Perceptual speech assessment: residual post-operative velopharyngeal insufficiency · Children or adolescents aged 3 years or older with velopharyngeal insufficiency (VPI) associated with non-syndromic submucous cleft palate
1 finding from 1 review
  • Interventions for the management of submucous cleft palate 2008 · Cochrane All outcomes
    3 months post-operatively
    Five (14%) of the participants in group 1 (MIPP) and four (11%) in group 2 had residual post-operative velopharyngeal insufficiency, P > 0.05. The report provided no details on post-operative speech assessment other…
    1 study · 72 participants
    GRADE not reported