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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

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No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

Gingival index (GI) · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

Periodontal treatment (scaling and root planing, alone or with… showed no clear difference in gingival index compared with alternative (less intensive) periodontal treatment, alone or with…; GRADE not reported.

1 finding from 1 review

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

Adverse effects of therapy · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

The review found no eligible studies for this question.

1 finding from 1 review

Zinc vs placebo

Health‐related quality of life · Patients with taste disturbances (dysgeusia/hypogeusia; idiopathic, zinc-deficient, or secondary to chronic renal failure)
1 finding from 1 review
  • Interventions for managing taste disturbances 2017 · Cochrane All outcomes
    Results (health-related quality of life): None of the studies reported data on health-related quality of life. Heckmann 2005 (zinc) reported that signs of depression were less severe (Beck Depression Inventory P<0.05;…
    1 study
    GRADE not reported

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Oral mucositis (severe) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… may leads to lower oral mucositis (severe) compared with placebo (low certainty).

3 findings from 1 review

Metal-free FDPs (lithium disilicate) vs Metal-ceramic FDPs

Bridge failure · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)

It is very uncertain whether metal-free FDPs (lithium disilicate) changes bridge failure compared with metal-ceramic FDPs (very low certainty).

2 findings from 1 review

Bonded molar tubes (attached with adhesive) vs Molar bands (cemented, e.g. with glass ionomer cement)

First time failure at participant level · Participants with full arch fixed orthodontic appliance(s) with molar tubes bonded to first or second permanent molars; excludes prior…

Bonded molar tubes (attached with adhesive) led to higher first time failure at participant level compared with molar bands (cemented, e.g. with glass ionomer cement); GRADE not reported.

1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Aesthetics: canine rated as abnormal tooth colour · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in aesthetics: canine rated as abnormal tooth colour compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review

Granulocyte-macrophage colony-stimulating factor (GM-CSF), higher dose (1260 to 12,600 micrograms) vs Granulocyte-macrophage colony-stimulating factor (GM-CSF), lower dose (12.6 to 126 micrograms)

Oral mucositis (severe) · breast cancer patients undergoing chemotherapy

Granulocyte-macrophage colony-stimulating factor (GM-CSF), higher… led to higher oral mucositis (severe) compared with granulocyte-macrophage colony-stimulating factor (GM-CSF), lower…; GRADE not reported.

1 finding from 1 review

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

Preterm birth < 35 weeks · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination
1 finding from 1 review

Metal-free implant-supported single crowns (zirconia veneered with feldspathic ceramic) vs Metal-ceramic implant-supported single crowns

Implant crown failure · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown
1 finding from 1 review

Chlorhexidine mouthrinse (any concentration; 0.05% to 0.2%) used in conjunction with mechanical oral hygiene procedures vs Placebo/control mouthrinse, or no mouthrinse (mechanical oral hygiene alone); controls pooled (protocol's separate comparisons versus mechanical oral hygiene alone and versus placebo/control merged)

Other adverse effects (taste disturbance, oral mucosal effects, burning sensation) · Children or adults with gingivitis or periodontitis capable of performing normal mechanical oral hygiene procedures (some with medical…
1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Dysphagia · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

Palifermin showed no clear difference in dysphagia compared with placebo; GRADE not reported.

1 finding from 1 review

Amifostine vs no treatment/placebo

Locoregional control · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

Amifostine showed no clear difference in locoregional tumour control compared with no treatment/placebo; GRADE not reported.

1 finding from 1 review

ART using composite resin vs Conventional treatment using composite resin

Restoration failure (primary dentition) · Children with carious primary teeth

It is very uncertain whether ART using composite resin changes restoration failure (primary dentition) compared with conventional treatment using composite resin (very low certainty).

1 finding from 1 review

Periodontal treatment (scaling and root planing, polishing, or surgery), alone or with oral hygiene counselling, antiseptics, or antimicrobials vs no treatment

Perinatal mortality · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

It is very uncertain whether periodontal treatment (scaling and root planing, polishing, or… changes perinatal mortality (including fetal and neonatal deaths up to the… compared with no treatment (very low certainty).

1 finding from 1 review

Polaprezinc vs Azulene oral rinse

Disability of oral intake · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

Polaprezinc showed no clear difference in disability of oral intake compared with azulene oral rinse; GRADE not reported.

1 finding from 1 review