Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,092 questions · 3,199 findings · 339 reviews · Headline outcomes only

No studies found 714 · 22.3%GRADE not reported 181 · 5.7%Very low 695 · 21.7%Low 908 · 28.4%Moderate 568 · 17.8%High 133 · 4.2%

Intervention not reported

Evidence of immunologic tolerance · adults with food allergy to fruits

The review found no eligible studies for this question.

1 finding from 1 review

Ultrasound or Doppler guidance vs anatomical landmarks

Complication rate total · patients with the need for subclavian vein cannulation for central vein catheterization

It is very uncertain whether ultrasound or Doppler guidance changes complication rate total compared with anatomical landmark (very low certainty).

1 finding from 1 review

Ultrasound or Doppler guidance vs anatomical landmarks

Overall success rate · patients with the need for subclavian vein cannulation for central vein catheterization

Ultrasound or Doppler guidance showed no clear difference in overall success rate compared with anatomical landmark (low certainty).

1 finding from 1 review

Ultrasound or Doppler guidance vs anatomical landmarks

Other complications (thrombosis, embolism, haematomediastinum and hydromediastinum, haematothorax and hydrothorax, pneumothorax, subcutaneous emphysema, nerve injury) · patients with the need for subclavian vein cannulation for central vein catheterization

It is very uncertain whether ultrasound or Doppler guidance changes other complications (thrombosis, embolism, haematomediastinum and… compared with anatomical landmark (very low certainty).

1 finding from 1 review

Ultrasound or Doppler guidance vs anatomical landmarks

First‐attempt success rate · patients with the need for subclavian vein cannulation for central vein catheterization

Ultrasound or Doppler guidance showed no clear difference in success with attempt number 1 compared with anatomical landmark (high certainty).

1 finding from 1 review

Intervention not reported

At least 50% of maximum pain relief over 4 to 6 h · Adults with acute pain

The intervention probably leads to higher at least 50% of maximum pain relief over 4 to 6 h (moderate certainty).

1 finding from 1 review

Intervention not reported

Pain Global pain 0‐3 (higher scores mean worse) · patients with treating osteoarthritis
1 finding from 1 review

Intervention not reported

Adverse events Adverse event episodes (n) reported · patients with treating osteoarthritis

The intervention probably leads to lower adverse events Adverse event episodes (n) reported (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events Participants (n) withdrew due to adverse effects · patients with treating osteoarthritis
1 finding from 1 review

Intervention not reported

Adverse events Participants (n) reported serious adverse events · patients with treating osteoarthritis
1 finding from 1 review