Findings

What do systematic reviews say?

4,783 questions · 10,022 findings · 882 reviews

Sort:Best matchNewest Highest certainty Download CSV

No studies found 2,100 · 21%GRADE not reported 1,013 · 10.1%Very low 2,237 · 22.3%Low 2,514 · 25.1%Moderate 1,709 · 17.1%High 449 · 4.5%

Ranked among the 5,000 newest matching findings; add words or filters to narrow the search.

Coenzyme Q10 vs placebo or conventional therapy

Adverse events · patients with heart failure

Coenzyme Q10 showed no clear difference in adverse events compared with placebo or conventional therapy (low certainty).

1 finding from 1 review

Coenzyme Q10 for heart failure 2021 · Cochrane Headline outcomes only
RR 0.7 [0.45, 1.1]
2 studies · 568 participants
Low

Autogenic drainage vs conventional physiotherapy

FEV1 % predicted: absolute change from baseline · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 54 participants
Very low

Autogenic drainage vs conventional physiotherapy

QoL · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 54 participants
Very low

Autogenic drainage vs conventional physiotherapy

Participant preference · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 36 participants
Very low

Autogenic drainage vs conventional physiotherapy

Exercise capacity · adults and children with CF

The review found no eligible studies for this question.

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Autogenic drainage vs conventional physiotherapy

Adverse events · adults and children with CF

The review found no eligible studies for this question.

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Autogenic drainage vs conventional physiotherapy

Hospital admissions · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 36 participants
Very low

Autogenic drainage vs conventional physiotherapy

Need for extra treatment · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 36 participants
Very low

HFNC vs standard oxygen therapy

In‐hospital mortality (up to 90 days; included studies reported in‐hospital mortality, and mortality up to 28 days and up to ICU discharge) · adults in the ICU, requiring respiratory support

HFNC showed no clear difference in in‐hospital mortality (up to 90 days; included studies reported… compared with standard oxygen therapy (moderate certainty).

1 finding from 1 review

High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes only
RR 0.96 [0.82, 1.11]
11 studies · 2673 participants
Moderate

HFNC vs standard oxygen therapy

Adverse events Respiratory infection (pneumonia) Nasal mucosa or skin trauma · adults in the ICU, requiring respiratory support

HFNC showed no clear difference in adverse events Respiratory infection (pneumonia) Nasal mucosa or… compared with standard oxygen therapy (moderate certainty).

1 finding from 1 review

High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes only
RR 0.72 [0.48, 1.09]
4 studies · 1057 participants
Moderate

HFNC vs standard oxygen therapy

Duration of ICU stay · adults in the ICU, requiring respiratory support

1 finding from 1 review

High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 1014 participants
Low

HFNC vs standard oxygen therapy

Comfort · adults in the ICU, requiring respiratory support

2 findings from 1 review

High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 662 participants
Very low
High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 445 participants
Very low

Afatinib vs chemotherapy alone

Overall survival · EGFR M+ patients with NSCLC

Afatinib showed no clear difference in overall survival compared with chemotherapy (high certainty).

1 finding from 1 review

First‐line treatment of advanced epidermal growth factor receptor (EGFR) mutation positive non‐squamous non‐small cell… 2021 · Cochrane Headline outcomes only
HR 0.91 [0.75, 1.1]
2 studies · 709 participants
High

Afatinib vs chemotherapy alone

Progression‐free survival · EGFR M+ patients with NSCLC

Afatinib leads to lower progression‐free survival compared with chemotherapy (high certainty).

1 finding from 1 review

First‐line treatment of advanced epidermal growth factor receptor (EGFR) mutation positive non‐squamous non‐small cell… 2021 · Cochrane Headline outcomes only
HR 0.42 [0.34, 0.53]
2 studies · 709 participants
High

Sertraline vs cognitive behavioural therapy

> 50% reduction in depressive symptoms · people with epilepsy and depression

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Sertraline vs cognitive behavioural therapy

Depressive symptoms · people with epilepsy and depression

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 117 participants
Moderate

Sertraline vs cognitive behavioural therapy

Seizure frequency · people with epilepsy and depression

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 96 participants
Low

Sertraline vs cognitive behavioural therapy

Treatment withdrawal · people with epilepsy and depression

Sertraline showed no clear difference in withdrawals compared with cognitive behavioural therapy (moderate certainty).

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
RR 1.26 [0.64, 2.46]
1 study · 140 participants
Moderate

Sertraline vs cognitive behavioural therapy

Cognitive function · people with epilepsy and depression

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Sertraline vs cognitive behavioural therapy

Quality of life (QOLIE‐89) (1‐ to 3‐month periods) · people with epilepsy and depression

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 118 participants
Moderate