Autogenic drainage vs conventional physiotherapy
Need for extra treatment · adults and children with CF
1 finding from 1 review
- no estimate extracted1 study · 36 participantsVery low
Findings
What do systematic reviews say?
4,771 questions · 10,185 findings · 893 reviews
No studies found 2,109 · 20.7%GRADE not reported 1,125 · 11%Very low 2,279 · 22.4%Low 2,514 · 24.7%Moderate 1,709 · 16.8%High 449 · 4.4%
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HFNC vs standard oxygen therapy
In‐hospital mortality (up to 90 days; included studies reported in‐hospital mortality, and mortality up to 28 days and up to ICU discharge) · adults in the ICU, requiring respiratory support
HFNC showed no clear difference in in‐hospital mortality (up to 90 days; included studies reported… compared with standard oxygen therapy (moderate certainty).
1 finding from 1 review
- High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes onlyRR 0.96 [0.82, 1.11]11 studies · 2673 participantsModerate
HFNC vs standard oxygen therapy
Adverse events Respiratory infection (pneumonia) Nasal mucosa or skin trauma · adults in the ICU, requiring respiratory support
HFNC showed no clear difference in adverse events Respiratory infection (pneumonia) Nasal mucosa or… compared with standard oxygen therapy (moderate certainty).
1 finding from 1 review
- High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes onlyRR 0.72 [0.48, 1.09]4 studies · 1057 participantsModerate
HFNC vs standard oxygen therapy
Duration of ICU stay · adults in the ICU, requiring respiratory support
1 finding from 1 review
- High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes onlyno estimate extracted7 studies · 1014 participantsLow
HFNC vs standard oxygen therapy
Comfort · adults in the ICU, requiring respiratory support
2 findings from 1 review
- High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes onlyno estimate extracted4 studies · 662 participantsVery low
- High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 445 participantsVery low
Afatinib vs chemotherapy alone
Overall survival · EGFR M+ patients with NSCLC
Afatinib showed no clear difference in overall survival compared with chemotherapy (high certainty).
1 finding from 1 review
- First‐line treatment of advanced epidermal growth factor receptor (EGFR) mutation positive non‐squamous non‐small cell… 2021 · Cochrane Headline outcomes onlyHR 0.91 [0.75, 1.1]2 studies · 709 participantsHigh
Afatinib vs chemotherapy alone
Progression‐free survival · EGFR M+ patients with NSCLC
Afatinib leads to lower progression‐free survival compared with chemotherapy (high certainty).
1 finding from 1 review
- First‐line treatment of advanced epidermal growth factor receptor (EGFR) mutation positive non‐squamous non‐small cell… 2021 · Cochrane Headline outcomes onlyHR 0.42 [0.34, 0.53]2 studies · 709 participantsHigh
Sertraline vs cognitive behavioural therapy
> 50% reduction in depressive symptoms · people with epilepsy and depression
1 finding from 1 review
- no estimate extracted0 studies · 0 participantsGRADE not reported
Sertraline vs cognitive behavioural therapy
Depressive symptoms · people with epilepsy and depression
1 finding from 1 review
- no estimate extracted1 study · 117 participantsModerate
Sertraline vs cognitive behavioural therapy
Seizure frequency · people with epilepsy and depression
1 finding from 1 review
- no estimate extracted1 study · 96 participantsLow
Sertraline vs cognitive behavioural therapy
Treatment withdrawal · people with epilepsy and depression
Sertraline showed no clear difference in withdrawals compared with cognitive behavioural therapy (moderate certainty).
1 finding from 1 review
- RR 1.26 [0.64, 2.46]1 study · 140 participantsModerate
Sertraline vs cognitive behavioural therapy
Cognitive function · people with epilepsy and depression
1 finding from 1 review
- no estimate extracted0 studies · 0 participantsGRADE not reported
Sertraline vs cognitive behavioural therapy
Quality of life (QOLIE‐89) (1‐ to 3‐month periods) · people with epilepsy and depression
1 finding from 1 review
- no estimate extracted1 study · 118 participantsModerate
Sertraline vs cognitive behavioural therapy
Adverse effects · people with epilepsy and depression
1 finding from 1 review
- no estimate extracted1 study · 118 participantsLow
Selective serotonin reuptake inhibitors vs cognitive behavioural therapy
> 50% reduction in depressive symptoms · people with epilepsy and depression
1 finding from 1 review
- no estimate extracted0 studies · 0 participantsGRADE not reported
Selective serotonin reuptake inhibitors vs cognitive behavioural therapy
Depressive symptoms · people with epilepsy and depression
1 finding from 1 review
- no estimate extracted15 participantsVery low
Selective serotonin reuptake inhibitors vs cognitive behavioural therapy
Seizure frequency · people with epilepsy and depression
1 finding from 1 review
- no estimate extracted15 participantsVery low
Selective serotonin reuptake inhibitors vs cognitive behavioural therapy
Treatment withdrawal · people with epilepsy and depression
It is very uncertain whether selective serotonin reuptake inhibitors changes withdrawals compared with cognitive behavioural therapy (very low certainty).
1 finding from 1 review
- RR 0.44 [0.05, 3.85]15 participantsVery low
Selective serotonin reuptake inhibitors vs cognitive behavioural therapy
Cognitive function · people with epilepsy and depression
1 finding from 1 review
- no estimate extracted0 studies · 0 participantsGRADE not reported
Selective serotonin reuptake inhibitors vs cognitive behavioural therapy
Post‐treatment quality of life (QOLIE‐31 score, which has a range of 0‐200, with higher score indicates better quality of life) ( · people with epilepsy and depression
1 finding from 1 review
- no estimate extracted15 participantsVery low