Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,372 questions · 3,874 findings · 666 reviews

No studies found 431 · 11.1%GRADE not reported 783 · 20.2%Very low 995 · 25.7%Low 909 · 23.5%Moderate 596 · 15.4%High 160 · 4.1%

Low tidal volume vs high tidal volume

Need for postoperative invasive ventilatory support · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

Low tidal volume probably leads to lower need for postoperative invasive ventilatory support compared with high tidal volume (moderate certainty).

1 finding from 1 review

Low tidal volume vs high tidal volume

Barotrauma (pneumothorax) · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

It is very uncertain whether low tidal volume changes barotrauma: pneumothorax compared with high tidal volume (very low certainty).

1 finding from 1 review

Intervention not reported

Major adverse cardiovascular events (MACE) · people with cardiovascular disease or at high risk of cardiovascular disease

The intervention probably leads to lower major adverse cardiovascular events (MACE) (moderate certainty).

1 finding from 1 review

Intervention not reported

Myocardial infarction (non‐fatal) · people with cardiovascular disease or at high risk of cardiovascular disease

The intervention probably leads to lower myocardial infarction (non‐fatal) (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events ‐ myopathy · people with cardiovascular disease or at high risk of cardiovascular disease

It is very uncertain whether the intervention changes adverse events ‐ myopathy (very low certainty).

1 finding from 1 review