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What do systematic reviews say?

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Evidence found and GRADE certainty

4,710 questions · 14,842 findings · 1,394 reviews

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No studies found 2,880 · 19.4%GRADE not reported 1,413 · 9.5%Very low 3,103 · 20.9%Low 3,870 · 26.1%Moderate 2,663 · 17.9%High 913 · 6.2%

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Intranasal steroid spray vs placebo or no intervention

Change in sense of smell · people with olfactory dysfunction for less than 4 weeks following COVID‐19 infection
3 findings from 1 review

Synbiotic vs placebo

Global improvement or treatment success, as defined by primary study · children with chronic constipation without a physical explanation

Synbiotics may leads to higher global improvement or treatment success, as defined by primary study compared with placebo (low certainty).

1 finding from 1 review

Probiotics vs placebo

Global improvement or treatment success, as defined by primary study · children with chronic constipation without a physical explanation

Probiotic may leads to higher global improvement/treatment success as defined by primary study compared with placebo (low certainty).

1 finding from 1 review

Probiotics vs placebo

Withdrawals due to adverse events · children with chronic constipation without a physical explanation

Probiotic showed no clear difference in withdrawals due to adverse events compared with placebo (low certainty).

1 finding from 1 review