Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,092 questions · 3,199 findings · 339 reviews · Headline outcomes only

No studies found 714 · 22.3%GRADE not reported 181 · 5.7%Very low 695 · 21.7%Low 908 · 28.4%Moderate 568 · 17.8%High 133 · 4.2%

FAE vs placebo

PASI score (scale range from 0 to 72 (higher score indicates more severe psoriasis)) · psoriasis
1 finding from 1 review

FAE vs MTX

Common nuisance AEs (not leading to treatment discontinuation) · psoriasis

It is very uncertain whether FAE changes common nuisance AEs (not leading to treatment discontinuation) compared with MTX (very low certainty).

1 finding from 1 review

FAE vs MTX

PASI 50 · psoriasis

It is very uncertain whether FAE changes PASI 50 compared with MTX (very low certainty).

1 finding from 1 review

FAE vs MTX

Percentage of participants reaching PASI 75 · psoriasis

It is very uncertain whether FAE changes PASI 75 compared with MTX (very low certainty).

1 finding from 1 review

FAE vs MTX

PASI 90 · psoriasis

It is very uncertain whether FAE changes PASI 90 compared with MTX (very low certainty).

1 finding from 1 review

FAE vs placebo

Common nuisance AEs (not leading to treatment discontinuation) · psoriasis

FAE probably leads to higher common nuisance AEs (not leading to treatment discontinuation) compared with placebo (moderate certainty).

1 finding from 1 review

FAE vs MTX

PASI score (scale range from 0 to 72 (higher score indicates more severe psoriasis)) · psoriasis
1 finding from 1 review

FAE vs MTX

Withdrawals due to adverse events · psoriasis

It is very uncertain whether FAE changes AEs leading to treatment discontinuation compared with MTX (very low certainty).

1 finding from 1 review

Summary of findings: Knee orthosis (any type) and exercise vs control (exercise only)

Pain at 3 to 6 months Scale from: 0 (no pain) to 10 (worse pain) · Adults (recruited from health clinics or military recruits) with PFPS (duration of symptoms ranged from acute, under 2 to 3 weeks in two…

It is very uncertain whether summary of findings: Knee orthosis (any type) and exercise changes pain score (VAS) Scale from: 0 to 10 (higher scores mean worse pain) compared with control (exercise only) (very low certainty).

1 finding from 1 review

Summary of findings: Knee orthosis (any type) and exercise vs control (exercise only)

Functional outcomes · Adults (recruited from health clinics or military recruits) with PFPS (duration of symptoms ranged from acute, under 2 to 3 weeks in two…

It is very uncertain whether summary of findings: Knee orthosis (any type) and exercise changes functional outcomes Scale various 2 compared with control (exercise only) (very low certainty).

1 finding from 1 review