Intervention not reported
2a. Adequate immune response (seroprotection) against diphtheria (surrogate outcome) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine
The intervention showed no clear difference in 2a. Adequate immune response (seroprotection) against diphtheria… (moderate certainty).
1 finding from 1 review
Intervention not reported
2b. Adequate immune response (seroprotection) against tetanus (surrogate outcome) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine
The intervention showed no clear difference in 2b. Adequate immune response (seroprotection) against tetanus… (moderate certainty).
1 finding from 1 review
Intervention not reported
2c. Adequate immune response (seroprotection) against pertussis (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
2d. Adequate immune response (seroprotection) against Haemophilus influenzae type b disease (surrogate outcome) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine
The intervention showed no clear difference in 2d. Adequate immune response (seroprotection) against Haemophilus… (moderate certainty).
1 finding from 1 review
Intervention not reported
Pain (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
4a. Procedural crying (during and immediately after the vaccination procedure) (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
2b. Adequate immune response (seroprotection) against tetanus (surrogate outcome) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine
The intervention showed no clear difference in 2b. Adequate immune response (seroprotection) against tetanus… (moderate certainty).
1 finding from 1 review
Intervention not reported
4b. Persistent inconsolable crying4 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine
It is very uncertain whether the intervention changes 4b. Persistent inconsolable crying4 (very low certainty).
1 finding from 1 review
Intervention not reported
Severe local reaction8 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine
The intervention probably leads to lower severe local reaction8 (moderate certainty).
1 finding from 1 review
Intervention not reported
Non‐severe local reaction11 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine
The intervention probably leads to lower non‐severe local reaction11 (moderate certainty).
1 finding from 1 review
Intervention not reported
Fever15 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine
It is very uncertain whether the intervention changes fever15 (very low certainty).
1 finding from 1 review
Intervention not reported
2c. Adequate immune response (seroprotection) against pertussis (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
2d. Adequate immune response (seroprotection) against Haemophilus influenzae type b disease (surrogate outcome) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine
The intervention probably leads to higher 2d. Adequate immune response (seroprotection) against Haemophilus… (moderate certainty).
1 finding from 1 review
Intervention not reported
Pain (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
4a. Procedural crying (during and immediately after the vaccination procedure) (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
4b. Persistent inconsolable crying4 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine
It is very uncertain whether the intervention changes 4b. Persistent inconsolable crying4 (very low certainty).
1 finding from 1 review
Intervention not reported
Severe local reaction8 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine
The intervention probably leads to lower severe local reaction8 (moderate certainty).
1 finding from 1 review
All‐cause mortality · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…
Low tidal volume showed no clear difference in mortality compared with high tidal volume (low certainty).
1 finding from 1 review
Pneumonia · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…
Low tidal volume probably leads to lower pneumonia compared with high tidal volume (moderate certainty).
1 finding from 1 review
Need for postoperative non‐invasive ventilatory support · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…
Low tidal volume probably leads to lower need for postoperative non‐invasive ventilatory support compared with high tidal volume (moderate certainty).
1 finding from 1 review