Vomiting · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
Amifostine may leads to higher vomiting (adverse effect) compared with no treatment/placebo (low certainty).
1 finding from 1 review
Time off school or work · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
The review found no eligible studies for this question.
1 finding from 1 review
Perinatal mortality · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination
It is very uncertain whether periodontal treatment (scaling and root planing, alone or with… changes perinatal mortality (including fetal and neonatal deaths up to the… compared with alternative (less intensive) periodontal treatment, alone or with… (very low certainty).
1 finding from 1 review
Secondary caries · Older adults with root caries in permanent (mature) teeth (mean age 75 years)
1 finding from 1 review
Taste acuity improvement - objective outcome (continuous) - taste detection (cross-over trial) · Patients with taste disturbances (dysgeusia/hypogeusia; idiopathic, zinc-deficient, or secondary to chronic renal failure)
It is very uncertain whether zinc supplements (zinc sulphate, zinc gluconate, zinc picolinate,… changes taste acuity improvement - objective outcome (continuous) - taste… compared with placebo (very low certainty).
1 finding from 1 review
Failure to complete orthodontic treatment due to pain · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
The review found no eligible studies for this question.
1 finding from 1 review
Quality of life and other oral related symptoms (loss of taste, dysphagia) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review
Oral mucositis (severe) · Adults receiving bone marrow/stem cell transplantation after conditioning therapy for haematological cancers
Erythropoietin mouthwash showed no clear difference in oral mucositis (severe) compared with placebo; GRADE not reported.
1 finding from 1 review
Gingival bleeding (various bleeding indices) · Children or adults with gingivitis or periodontitis capable of performing normal mechanical oral hygiene procedures (some with medical…
Chlorhexidine mouthrinse (any concentration; 0.05% to 0.2%) used in… led to lower gingival bleeding (various bleeding indices) compared with placebo/control mouthrinse, or no mouthrinse (mechanical oral…; GRADE not reported.
2 findings from 1 review
Patient response: moderate or severe pain at 1 day postoperative · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)
Open surgical exposure showed no clear difference in patient response: moderate or severe pain at 1 day postoperative compared with closed surgical exposure; GRADE not reported.
1 finding from 1 review
Adverse events · Children with carious primary teeth
The review found no eligible studies for this question.
1 finding from 1 review
Dentine caries in permanent molars (24 months) · Children and adolescents (general population, aged under 20 years)
1 finding from 1 review
Inconclusive results: two studies slightly favoured glass ionomers (Liu 2014b OR 0.46 (0.23-0.91); Tagliaferro 2011) evaluating 426 children; one study (Songpaisan 1995) found no difference (MD DFS -0.18 (-0.39 to…
3 studies · 830 participants
Very low
Taste discrimination improvement · Patients with idiopathic dysgeusia and hypogeusia
It is very uncertain whether acupuncture changes taste discrimination improvement compared with sham control (deactivated laser sham acupuncture) (very low certainty).
2 findings from 1 review
Oral mucositis (severe) · Adults receiving radiotherapy to the head and neck
Granulocyte-macrophage colony-stimulating factor (GM-CSF), mouthwash showed no clear difference in oral mucositis (severe) compared with sucralfate mouthwash; GRADE not reported.
1 finding from 1 review
Normalcy of diet (supplemental nutrition: TPN, PEG, nasogastric tube or IV hydration) · Adults with cancer receiving treatment
Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in normalcy of diet (supplemental nutrition: TPN, PEG, nasogastric tube… compared with placebo; GRADE not reported.
1 finding from 1 review
Treatment time: duration of orthodontic treatment (placement to removal of fixed appliances) · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)
Open surgical exposure showed no clear difference in treatment time: duration of orthodontic treatment (placement to… compared with closed surgical exposure; GRADE not reported.
1 finding from 1 review
Oral mucositis (any severity) · Adults receiving chemotherapy alone for colorectal cancer
Transforming growth factor-beta(2) (TGF-beta2) showed no clear difference in oral mucositis (any severity) compared with placebo; GRADE not reported.
1 finding from 1 review
Quality of life or participant satisfaction · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
The review found no eligible studies for this question.
1 finding from 1 review
Quality of life or participant satisfaction · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
The review found no eligible studies for this question.
1 finding from 1 review
Taste acuity improvement - patient-reported outcome · Patients with taste disturbances (dysgeusia/hypogeusia; idiopathic, zinc-deficient, or secondary to chronic renal failure)
It is very uncertain whether zinc supplements (zinc sulphate, zinc gluconate, zinc picolinate,… changes taste acuity improvement - patient-reported outcome compared with placebo (very low certainty).
1 finding from 1 review