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What do systematic reviews say?

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Evidence found and GRADE certainty

4,721 questions · 19,640 findings · 2,039 reviews · Headline outcomes only

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No studies found 3,754 · 19.1%GRADE not reported 1,273 · 6.5%Very low 4,859 · 24.7%Low 5,568 · 28.4%Moderate 3,240 · 16.5%High 946 · 4.8%

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Antibiotics vs control

Sore throat · patients with sore throat

Antibiotics probably leads to lower sore throat: day 3 compared with control (moderate certainty).

2 findings from 1 review

Anticoagulant vs control

Dead or dependent · acute presumed ischaemic stroke

Summary of findings table ‐ Anticoagulant showed no clear difference in dead or dependent at end of compared with control (high certainty).

1 finding from 1 review

Anticoagulant vs control

Death during study period · acute presumed ischaemic stroke

Summary of findings table ‐ Anticoagulant showed no clear difference in death from all causes during treatment period compared with control (low certainty).

1 finding from 1 review

Anticoagulant vs control

Deep vein thrombosis · acute presumed ischaemic stroke

It is very uncertain whether summary of findings table ‐ Anticoagulant changes deep vein thrombosis during treatment period compared with control (very low certainty).

1 finding from 1 review

Anticoagulant vs control

Recurrent ischaemic or unknown stroke during treatment period · acute presumed ischaemic stroke

Summary of findings table ‐ Anticoagulant probably leads to lower recurrent ischaemic or unknown stroke during treatment period compared with control (moderate certainty).

1 finding from 1 review

Anticoagulant vs control

Symptomatic intracranial haemorrhage during treatment period · acute presumed ischaemic stroke

Summary of findings table ‐ Anticoagulant probably leads to higher symptomatic intracranial haemorrhage during treatment period compared with control (moderate certainty).

1 finding from 1 review

Anticoagulant vs control

Symptomatic PE · acute presumed ischaemic stroke

Summary of findings table ‐ Anticoagulant leads to lower symptomatic pulmonary embolism during treatment period compared with control (high certainty).

1 finding from 1 review

Anticoagulant vs control

Major extracranial haemorrhage during treatment period · acute presumed ischaemic stroke

Summary of findings table ‐ Anticoagulant probably leads to higher major extracranial haemorrhage during treatment period compared with control (moderate certainty).

1 finding from 1 review