Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,234 questions · 3,357 findings · 396 reviews

No studies found 803 · 23.9%GRADE not reported 270 · 8%Very low 757 · 22.5%Low 859 · 25.6%Moderate 486 · 14.5%High 182 · 5.4%

Levosimendan vs placebo

All‐cause long‐term mortality: range 4 to 6 months · adults with cardiogenic shock or low cardiac output syndrome

It is very uncertain whether levosimendan changes all‐cause long‐term mortality: range 4 to 6 months compared with placebo (very low certainty).

1 finding from 1 review

Epinephrine vs norepinephrine‐dobutamine

All‐cause short‐term mortality: 28 days · adults with cardiogenic shock

It is very uncertain whether epinephrine changes all‐cause short‐term mortality: 28 days compared with norepinephrine‐dobutamine (very low certainty).

1 finding from 1 review

Intervention not reported

Ototoxicity An increase in auditory threshold of 20 dB or more over any frequency range · adults and children with cystic fibrosis

The intervention showed no clear difference in ototoxicity An increase in auditory threshold of 20 dB or more over… (low certainty).

1 finding from 1 review