Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,721 questions · 19,640 findings · 2,039 reviews · Headline outcomes only

No studies found 3,754 · 19.1%GRADE not reported 1,273 · 6.5%Very low 4,859 · 24.7%Low 5,568 · 28.4%Moderate 3,240 · 16.5%High 946 · 4.8%

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Full opioid agonists vs different full opioid agonists or partial opioid agonists (methadone versus buprenorphine)

Adverse effects · pharmaceutical opioid dependent people

Full opioid agonists showed no clear difference in adverse effects compared with different full opioid agonists or partial opioid agonists (methadone… (low certainty).

1 finding from 1 review

Full or partial opioid agonist maintenance vs placebo, detoxification only or psychological treatment (buprenorphine maintenance compared to taper or treatment

Days of unsanctioned opioid use · pharmaceutical opioid dependent people

Full or partial opioid agonist maintenance showed no clear difference in days of unsanctioned opioid use (as number of days/30 or days/7) compared with placebo, detoxification only or psychological treatment… (low certainty).

1 finding from 1 review

Full or partial opioid agonist maintenance vs placebo, detoxification only or psychological treatment (buprenorphine maintenance compared to taper or treatment

Opioid use · pharmaceutical opioid dependent people

It is very uncertain whether full or partial opioid agonist maintenance changes self‐reported opioid use at treatment completion compared with placebo, detoxification only or psychological treatment… (very low certainty).

2 findings from 1 review

Full or partial opioid agonist maintenance vs placebo, detoxification only or psychological treatment (buprenorphine maintenance compared to taper or treatment

Retention in treatment · pharmaceutical opioid dependent people

Full or partial opioid agonist maintenance probably leads to higher retention: proportion of participants retained in treatment compared with placebo, detoxification only or psychological treatment… (moderate certainty).

1 finding from 1 review

Intervention not reported

Delayed gastric emptying (all definitions) · adults with any pancreatic diagnosis leading to an indication for elective (classical, pylorus‐preserving, pylorus‐resecting) partial…

The intervention showed no clear difference in delayed gastric emptying (all definitions) (low certainty).

1 finding from 1 review

Intervention not reported

Mortality (within 30 days or 'in‐hospital') · adults with any pancreatic diagnosis leading to an indication for elective (classical, pylorus‐preserving, pylorus‐resecting) partial…

The intervention showed no clear difference in mortality (within 30 days or 'in‐hospital') (high certainty).

1 finding from 1 review

Intervention not reported

Pancreatic fistula · adults with any pancreatic diagnosis leading to an indication for elective (classical, pylorus‐preserving, pylorus‐resecting) partial…

The intervention showed no clear difference in pancreatic fistula (low certainty).

1 finding from 1 review

Intervention not reported

Postoperative haemorrhage · adults with any pancreatic diagnosis leading to an indication for elective (classical, pylorus‐preserving, pylorus‐resecting) partial…

The intervention showed no clear difference in postoperative haemorrhage (low certainty).

1 finding from 1 review

Intervention not reported

Intra‐abdominal fluid collection, abscess · adults with any pancreatic diagnosis leading to an indication for elective (classical, pylorus‐preserving, pylorus‐resecting) partial…

The intervention showed no clear difference in intra‐abdominal fluid collection, abscess (low certainty).

1 finding from 1 review

Intervention not reported

Reoperations · adults with any pancreatic diagnosis leading to an indication for elective (classical, pylorus‐preserving, pylorus‐resecting) partial…

The intervention showed no clear difference in reoperations (low certainty).

1 finding from 1 review

Intervention not reported

Length of postoperative hospital stay (days) · adults with any pancreatic diagnosis leading to an indication for elective (classical, pylorus‐preserving, pylorus‐resecting) partial…

The intervention showed no clear difference in length of postoperative hospital stay (days) (low certainty).

1 finding from 1 review

Intervention not reported

Quality of life (EQ‐5D, EORTC QLQ‐C30 and PAN26, GIQLI at 2, 4 and 12 weeks after surgery) · adults with any pancreatic diagnosis leading to an indication for elective (classical, pylorus‐preserving, pylorus‐resecting) partial…
1 finding from 1 review