Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,315 questions · 23,557 findings · 2,311 reviews

No studies found 4,183 · 17.8%GRADE not reported 3,930 · 16.7%Very low 5,371 · 22.8%Low 5,787 · 24.6%Moderate 3,320 · 14.1%High 966 · 4.1%

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Antiplatelet agent vs control

Fatal or nonfatal stroke · people with chronic kidney disease (predialysis (GFR 15 to 60 mL/min/1.73 m²), HD, PD, transplant recipients)

It is very uncertain whether antiplatelet agents changes fatal or nonfatal stroke compared with control (very low certainty).

1 finding from 1 review

Antiplatelet agent vs control

Death (any cause) · people with chronic kidney disease (predialysis (GFR 15 to 60 mL/min/1.73 m²), HD, PD, transplant recipients)

Antiplatelet agents showed no clear difference in death (any cause) compared with control (low certainty).

1 finding from 1 review

Antiplatelet agent vs control

Cardiovascular mortality · people with chronic kidney disease (predialysis (GFR 15 to 60 mL/min/1.73 m²), HD, PD, transplant recipients)

It is very uncertain whether antiplatelet agents changes cardiovascular death compared with control (very low certainty).

1 finding from 1 review

Antiplatelet agent vs control

Major bleeding · people with chronic kidney disease (predialysis (GFR 15 to 60 mL/min/1.73 m²), HD, PD, transplant recipients)

Antiplatelet agents probably leads to higher major bleeding compared with control (moderate certainty).

1 finding from 1 review

Antiplatelet agent vs control

Minor bleeding · people with chronic kidney disease (predialysis (GFR 15 to 60 mL/min/1.73 m²), HD, PD, transplant recipients)

Antiplatelet agents may leads to higher minor bleeding compared with control (low certainty).

1 finding from 1 review

Antiplatelet agent vs control

Early access thrombosis (before 8 weeks) · people with chronic kidney disease (predialysis (GFR 15 to 60 mL/min/1.73 m²), HD, PD, transplant recipients)

Antiplatelet agents may leads to lower early access thrombosis (before 8 weeks) compared with control (low certainty).

1 finding from 1 review

Oral drug treatment vs topical treatments

Primary outcome 2: Clinical recurrence at 6 months · non‐pregnant women with a diagnosis of recurrent vulvovaginal candidiasis

It is very uncertain whether oral drug treatment changes primary outcome 2: Clinical recurrence at 6 months compared with topical drug treatment (very low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

CAS improvement (decrease) by 2 or more points · thyroid‐associated ophthalmopathy

Summary of findings table ‐ Rituximab showed no clear difference in CAS improvement (decrease) by 2 or more points compared with intravenous methylprednisolone (low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

NOSPECS improvement (decrease) by 2 classes or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes NOSPECS improvement (decrease) by 2 or more classes compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

Proptosis improvement (decrease) by 2 mm or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes proptosis improvement (decrease) by 2 mm or more compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

Palpebral aperture improvement (decrease) by 3 mm or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes palpebral aperture improvement (decrease) by 3 mm or more compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

Motility improvement (increase) by 1 class or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes motility improvement (increase) by 1 class or more compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review