Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,973 questions · 3,072 findings · 410 reviews · Headline outcomes only

No studies found 559 · 18.2%GRADE not reported 143 · 4.7%Very low 654 · 21.3%Low 833 · 27.1%Moderate 683 · 22.2%High 200 · 6.5%

Indacaterol vs placebo

Quality of life: number of participants with clinically significant improvement (≥ 4 units) in SGRQ total score · patients with chronic obstructive pulmonary disease

Indacaterol leads to higher number of participants with a clinically significant improvement in… compared with placebo (high certainty).

1 finding from 1 review

Indacaterol vs placebo

Improvement in symptoms: number of participants with clinically significant improvement: using TDI focal score (≥ 1 unit) · patients with chronic obstructive pulmonary disease

Indacaterol leads to higher number of participants with clinically significant improvement in… compared with placebo (high certainty).

1 finding from 1 review

Indacaterol vs placebo

Exacerbations (number of people experiencing ≥ 1 exacerbations) · patients with chronic obstructive pulmonary disease

Indacaterol leads to lower number of participants experiencing 1 or more exacerbations compared with placebo (high certainty).

1 finding from 1 review

Preoperative inspiratory muscle training vs usual care, non‐exercise intervention

Postoperative atelectasis original authors’ definitions · adult participants undergoing cardiac and major abdominal surgery

Preoperative inspiratory muscle training may leads to lower postoperative atelectasis original authors’ definitions compared with usual care, non‐exercise intervention (low certainty).

1 finding from 1 review

Preoperative inspiratory muscle training vs usual care, non‐exercise intervention

Postoperative pneumonia original authors’ definitions · adult participants undergoing cardiac and major abdominal surgery

Preoperative inspiratory muscle training probably leads to lower postoperative pneumonia original authors’ definitions compared with usual care, non‐exercise intervention (moderate certainty).

1 finding from 1 review

Preoperative inspiratory muscle training vs usual care, non‐exercise intervention

Mechanical ventilation > 48 hours · adult participants undergoing cardiac and major abdominal surgery

It is very uncertain whether preoperative inspiratory muscle training changes mechanical ventilation > 48 hours compared with usual care, non‐exercise intervention (very low certainty).

1 finding from 1 review

Preoperative inspiratory muscle training vs usual care, non‐exercise intervention

Mortality In the early postoperative period (≤ 30 days) · adult participants undergoing cardiac and major abdominal surgery

It is very uncertain whether preoperative inspiratory muscle training changes all‐cause mortality within 30 days during postoperative period compared with usual care, non‐exercise intervention (very low certainty).

1 finding from 1 review

Intervention not reported

Quality of life (dyspnoea) Measured on the CRQ, the output is a number from 0 to 7, where higher on the scale is better. MID is 0.5. · adults with COPD who had exertional dyspnoea but did not fulfil the criteria for long‐term oxygen treatment

The intervention probably leads to higher quality of life (dyspnoea) Measured on the CRQ, the output is a… (moderate certainty).

1 finding from 1 review