Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,721 questions · 19,640 findings · 2,039 reviews · Headline outcomes only

No studies found 3,754 · 19.1%GRADE not reported 1,273 · 6.5%Very low 4,859 · 24.7%Low 5,568 · 28.4%Moderate 3,240 · 16.5%High 946 · 4.8%

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Rituximab vs intravenous methylprednisolone

CAS improvement (decrease) by 2 or more points · thyroid‐associated ophthalmopathy

Summary of findings table ‐ Rituximab showed no clear difference in CAS improvement (decrease) by 2 or more points compared with intravenous methylprednisolone (low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

NOSPECS improvement (decrease) by 2 classes or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes NOSPECS improvement (decrease) by 2 or more classes compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

Proptosis improvement (decrease) by 2 mm or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes proptosis improvement (decrease) by 2 mm or more compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

Palpebral aperture improvement (decrease) by 3 mm or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes palpebral aperture improvement (decrease) by 3 mm or more compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

Motility improvement (increase) by 1 class or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes motility improvement (increase) by 1 class or more compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review

Routine vaginal examination vs routine rectal examination

Spontaneous vaginal birth · pregnant women in labour at term

It is very uncertain whether routine vaginal examination changes spontaneous vaginal birth (primary outcome)№ of participants: 307(1… compared with routine rectal examination (very low certainty).

1 finding from 1 review

Routine vaginal examination vs routine rectal examination

Neonatal infection · pregnant women in labour at term

It is very uncertain whether routine vaginal examination changes neonatal infection (primary outcome)№ of participants: 307(1 RCT) compared with routine rectal examination (very low certainty).

1 finding from 1 review

Routine vaginal examination vs routine rectal examination

Admission to neonatal intensive care unit · pregnant women in labour at term

It is very uncertain whether routine vaginal examination changes admission to neonatal intensive care unit№ of participants: 307(1 RCT) compared with routine rectal examination (very low certainty).

1 finding from 1 review

Routine 4‐hourly vaginal examinations vs routine 2‐hourly vaginal examinations

Augmentation of labour (primary outcome)№ of participants: (0 studies) · primiparous pregnant women in labour at term

It is very uncertain whether routine 4‐hourly vaginal examinations changes augmentation of labour (primary outcome)№ of participants: 109(1 RCT) compared with routine 2‐hourly vaginal examinations (very low certainty).

1 finding from 1 review

Routine 4‐hourly vaginal examinations vs routine 2‐hourly vaginal examinations

Spontaneous vaginal birth · primiparous pregnant women in labour at term

It is very uncertain whether routine 4‐hourly vaginal examinations changes spontaneous vaginal birth (primary outcome)№ of participants: 150(1… compared with routine 2‐hourly vaginal examinations (very low certainty).

1 finding from 1 review