Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,783 questions · 10,022 findings · 882 reviews

No studies found 2,100 · 21%GRADE not reported 1,013 · 10.1%Very low 2,237 · 22.3%Low 2,514 · 25.1%Moderate 1,709 · 17.1%High 449 · 4.5%

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Later vs earlier initiation of dexamethasone therapy

Death or bronchopulmonary dysplasia at 36 weeks PMA · preterm infants at risk for bronchopulmonary dysplasia

Later showed no clear difference in death or bronchopulmonary dysplasia at 36 weeks' PMA compared with earlier initiation of dexamethasone therapy (low certainty).

1 finding from 1 review

Later vs earlier initiation of dexamethasone therapy

Death or cerebral palsy at 1 to 3 years · preterm infants at risk for bronchopulmonary dysplasia

Later showed no clear difference in death or cerebral palsy at 1 to 3 years compared with earlier initiation of dexamethasone therapy (low certainty).

1 finding from 1 review

Later vs earlier initiation of dexamethasone therapy

Death or abnormal neurodevelopmental outcome (various definitions) · preterm infants at risk for bronchopulmonary dysplasia

Later showed no clear difference in death or abnormal neurodevelopmental outcome (various definitions) compared with earlier initiation of dexamethasone therapy (low certainty).

1 finding from 1 review

Pulse vs continuous dexamethasone therapy

Death or bronchopulmonary dysplasia at 36 weeks PMA · preterm infants at risk for bronchopulmonary dysplasia

Pulse may leads to higher death or bronchopulmonary dysplasia at 36 weeks' PMA compared with continuous dexamethasone therapy (low certainty).

1 finding from 1 review

Pulse vs continuous dexamethasone therapy

Death or abnormal neurodevelopmental outcome (various definitions) · preterm infants at risk for bronchopulmonary dysplasia

It is very uncertain whether pulse changes death or abnormal neurodevelopmental outcome (various definitions) compared with continuous dexamethasone therapy (very low certainty).

1 finding from 1 review

Intervention not reported

Nicotine patch · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…

The intervention showed no clear difference in nicotine patch (low certainty).

1 finding from 1 review

Intervention not reported

Fast‐acting NRT (nicotine other) · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…

The intervention showed no clear difference in fast‐acting NRT (nicotine other) (low certainty).

1 finding from 1 review

Intervention not reported

Bupropion · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…

The intervention showed no clear difference in bupropion (moderate certainty).

1 finding from 1 review