Search review questions

Individualised measures of performance ‐ not measured · children with unilateral cerebral palsy

Adverse events · children with unilateral cerebral palsy

Unimanual capacity · children with unilateral cerebral palsy

Manual ability ‐ not measured · children with unilateral cerebral palsy

Self‐care ‐ not measured · children with unilateral cerebral palsy

Individualised measures of performance ‐ not measured · children with unilateral cerebral palsy

Adverse events · children with unilateral cerebral palsy

Bimanual performance · children with unilateral cerebral palsy

Unimanual capacity · children with unilateral cerebral palsy

Teacher‐rated social skills Measured by: Conners Behavior Rating Scale: Social Problems Index; Strength and Difficulties Questionnaire: Prosocial Behaviour Subscale (teacher‐rated); Social Skills Improvement System; Social Skills Rating Scale: Coo... · children aged five to 18 years with ADHD

Parent‐rated social skills Measured by: Social Skills Rating Scale; Weiss Functional Impairment Scale: Social Acitivities Domain (parent‐rated); Strength and Difficulties Questionnaire: Prosocial Behavior Subscale; Social Skills Improvement System · children aged five to 18 years with ADHD

Teacher‐rated emotional competencies Measured by: Strengths and Difficulties Questionnaire: Emotional Symptoms Subscale; Conners Behavior Rating Scale: Emotional Index Score · children aged five to 18 years with ADHD

Teacher‐rated general behaviour Measured by: Self‐Control Rating Scale; Conners Behavior Rating Scale: Aggressiveness Index; Disruptive Behavior Disorders Rating Scale; Conners Teacher Rating Scale: Conduct Problems Index; Strengths and Difficulti... · children aged five to 18 years with ADHD

Parent‐rated general behaviour Measured by: Strengths and Difficulties Questionnaire (parent‐rated; total scores); Conners Behavior Rating Scale: Aggressiveness Index; Disruptive Behavior Disorders Rating Scale; Behavior Rating Inventory of Execut... · children aged five to 18 years with ADHD

Teacher‐rated ADHD symptoms Measured by: Disruptive Behavior Disorders Rating Scale; ADHD Rating Scales: Hyperactivity and Impulsivity Subscales (total scores); Conner Teacher Rating Scale: Hyperactivity Index; Strengths and Weaknesses of ADHD Sym... · children aged five to 18 years with ADHD

Parent‐rated ADHD symptoms Measured by: Conners Parent Rating Scale: Hyperkinesis Index; Disruptive Behavior Disorders Rating Scale; Strengths and Weaknesses of ADHD Symptoms and Normal Behaviors; Sluggish Cognitive Tempo; ADHD Symptom Checklist; ... · children aged five to 18 years with ADHD

Recovery during intervention defined as achieving WHZ ≥ −2 and absence of oedema in 1 study; reaching a WHZ score > −2 and without oedema in 1 study; WHZ > −2 in 1 study; having a WHZ score ≥ 0 in 1 study; reaching 100% weight for height in 1 stud... · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients…

Relapse during intervention defined as admission to inpatient therapeutic care, remain wasted, and dropouts during intervention period · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients…

Mortality during intervention · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients…

Rate of weight gain (g/kg/day) during intervention defined as change over first 4, 8, 10, 16 weeks of the intervention period in 4 studies; change until end of intervention period (no maximum number of weeks applied) in 1 study; and regression ana... · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients…

Relapse during intervention defined as admission to inpatient therapeutic care or recurrence of oedema or systematic infections during the study period, and dropouts during intervention period · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients…

Mortality during intervention · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients…

Rate of weight gain (g/kg/day) during intervention 3 studies measured weight gain during the first 4 weeks of the intervention period and 1 study until recovery or 16 weeks after enrolment, whichever was earlier · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients…

Recovery during intervention defined as WHZ > 0 in 1 study; 100% weight for height in 1 study · children aged 6 months‐5 years with SAM (1 study included HIV‐uninfected children; 1 study included HIV‐infected…

Relapse during intervention defined as admission to inpatient therapeutic care or recurrence of oedema or systematic infections during the study period, and dropouts during intervention period · children aged 6 months‐5 years with SAM (1 study included HIV‐uninfected children; 1 study included HIV‐infected…

Mortality during intervention · children aged 6 months‐5 years with SAM (1 study included HIV‐uninfected children; 1 study included HIV‐infected…

Rate of weight gain (g/kg/day) during intervention defined as change between baseline and week 4 of the intervention period · children aged 6 months‐5 years with SAM (1 study included HIV‐uninfected children; 1 study included HIV‐infected…

Recovery during intervention defined as weight gain ≥ 15% in relation to baseline weight, absence of complications and oedema, and MUAC > 110 mm in 2 studies; MUAC > 12.4 cm without oedema in 1 study; WHZ ≥ 80% for two consecutive visits in 1 stud... · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients…

Anaemia (haemoglobin concentration below a cut‐off defined by the trialists, adjusted by altitude and smoking as appropriate) · adolescent and adult menstruating women

Iron deficiency (as defined by the trialists using indicators of iron status such as ferritin or transferrin) · adolescent and adult menstruating women

Ferritin (µg/L) · adolescent and adult menstruating women

Iron deficiency anaemia (as defined by the presence of anaemia plus iron deficiency, diagnosed with an indicator of iron status selected by the trialists) · adolescent and adult menstruating women

All‐cause morbidity (the most frequent event associated with the intervention, independent of the cause, as defined by the trialists) · adolescent and adult menstruating women

Any adverse side effects · adolescent and adult menstruating women

Haemoglobin (g/L) · adolescent and adult menstruating women

Iron deficiency (as defined by trialists by using indicators of iron status such as ferritin or transferrin) · adolescent and adult menstruating women

Ferritin (µg/L) · adolescent and adult menstruating women

Iron deficiency anaemia (as defined by the presence of anaemia plus iron deficiency diagnosed with an indicator of iron status selected by the trialists) · adolescent and adult menstruating women

All‐cause morbidity (the most frequent event associated with the intervention, independent of the cause, as defined by the trialists) · adolescent and adult menstruating women

Any adverse side effects · adolescent and adult menstruating women

Anaemia (haemoglobin concentration below a cut‐off defined by the trialists, adjusted by altitude and smoking as appropriate) · adolescent and adult menstruating women

Haemoglobin (g/L) · adolescent and adult menstruating women

Paralytic wild polio cases (Change in slope at 3 years) · infants

Persons with protective humoral response (Range of · infants

Neutralising antibodies with 2 IPV doses Geometric mean titres ( · infants

Persons with faecal polio excretion after OPV challenge (Range of · infants

Vaccination coverage · infants

Serious adverse events (≥ 1 symptom related to study drug or not) (Range of · infants

Paralytic polio · preventing poliomyelitis

VAPP cases · preventing poliomyelitis