Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

503 questions · 676 findings · 22 reviews · Periodontology

No studies found 148 · 21.9%GRADE not reported 342 · 50.6%Very low 118 · 17.5%Low 45 · 6.7%Moderate 11 · 1.6%High 12 · 1.8%

Routine scale and polish at a fixed interval vs No scheduled scale and polish treatment

Gingivitis · Dentate adults without severe periodontitis, regularly attending for dental care in primary care (UK general dental practice)

Planned, regular routine scale and polish (6-monthly; 12-monthly… showed no clear difference in gingivitis compared with no scheduled scale and polish treatment (high certainty).

1 finding from 1 review

Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG) vs OFD + BG (open flap debridement + bone graft)

Change in radiographic bone defect filling (RBF) (%) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

Autologous platelet concentrates (APC) + open flap debridement (OFD)… led to higher change in radiographic bone defect filling (RBF) (%) compared with OFD + BG (open flap debridement + bone graft); GRADE not reported.

3 findings from 1 review

Autologous platelet concentrates (APC) + guided tissue regeneration (GTR) vs GTR (guided tissue regeneration) alone

Attachment change · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

It is very uncertain whether autologous platelet concentrates (APC) + guided tissue regeneration… changes change in clinical attachment level (CAL) (mm) compared with GTR (guided tissue regeneration) alone (very low certainty).

3 findings from 1 review

Routine scale and polish at a fixed interval vs No scheduled scale and polish treatment

Costs · Dentate adults without severe periodontitis, regularly attending for dental care in primary care (UK general dental practice)

It is very uncertain whether planned, regular routine scale and polish (6-monthly; 12-monthly… changes costs (NHS perspective, GBP) compared with no scheduled scale and polish treatment (very low certainty).

1 finding from 1 review

Routine scale and polish every 6 months vs Routine scale and polish every 12 months

Oral health-related quality of life · Dentate adults without severe periodontitis, regularly attending for dental care in primary care (UK general dental practice)

Routine scale and polish every 6 months showed no clear difference in oral health-related quality of life (OHIP-14) compared with routine scale and polish every 12 months (high certainty).

1 finding from 1 review

SPT using one technique or appliance for mechanical root debridement vs SPT using a different technique or appliance for mechanical root debridement

Outcome not reported · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)

The review found no eligible studies for this question.

1 finding from 1 review

SPT performed by non-specialist clinicians (general dental practitioners under specialist prescription) vs SPT performed by specialists (specialist practice)

Percentage of bleeding on probing (BOP) · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)

It is very uncertain whether SPT performed by non-specialist clinicians (general dental… changes bleeding on probing (%) compared with SPT performed by specialists (specialist practice) (very low certainty).

1 finding from 1 review

SPT performed by non-specialist clinicians (general dental practitioners under specialist prescription) vs SPT performed by specialists (specialist practice)

Probing pocket depth · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)

It is very uncertain whether SPT performed by non-specialist clinicians (general dental… changes probing pocket depth (mm) compared with SPT performed by specialists (specialist practice) (very low certainty).

1 finding from 1 review

Autologous platelet concentrates (APC) + enamel matrix derivative (EMD) vs EMD (enamel matrix derivative) alone

Attachment change · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

It is very uncertain whether autologous platelet concentrates (APC) + enamel matrix derivative… changes change in clinical attachment level (CAL) (mm) compared with EMD (enamel matrix derivative) alone (very low certainty).

1 finding from 1 review

Autologous platelet concentrates (APC) + guided tissue regeneration (GTR) vs GTR (guided tissue regeneration) alone

Pocket closure (complete pocket closure) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
1 finding from 1 review

Routine scale and polish at a fixed interval vs No scheduled scale and polish treatment

Participant satisfaction (perceived oral cleanliness) · Dentate adults without severe periodontitis, regularly attending for dental care in primary care (UK general dental practice)

Planned, regular routine scale and polish (6-monthly; 12-monthly… may leads to higher participant satisfaction (perceived oral cleanliness) compared with no scheduled scale and polish treatment (low certainty).

1 finding from 1 review

Routine scale and polish provided by a dentist vs Routine scale and polish provided by a dental care professional (dental therapist or hygienist)

Oral health-related quality of life · Dentate adults without severe periodontitis, regularly attending for dental care in primary care (UK general dental practice)

The review found no eligible studies for this question.

1 finding from 1 review

Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG) vs OFD + BG (open flap debridement + bone graft)

Attachment change · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

It is very uncertain whether autologous platelet concentrates (APC) + open flap debridement (OFD)… changes change in clinical attachment level (CAL) (mm) compared with OFD + BG (open flap debridement + bone graft) (very low certainty).

3 findings from 1 review

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

Percentage of bleeding on probing (BOP) · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)

It is very uncertain whether mechanical debridement plus local antimicrobial (minocycline… changes bleeding on probing (ratios) compared with mechanical debridement alone (very low certainty).

1 finding from 1 review

Supportive periodontal therapy (SPT) including mechanical debridement vs Monitoring only, or alternative interventions that do not include mechanical debridement

Outcome not reported · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)

The review found no eligible studies for this question.

1 finding from 1 review

Autologous platelet concentrates (APC) + guided tissue regeneration (GTR) vs GTR (guided tissue regeneration) alone

Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

The review found no eligible studies for this question.

1 finding from 1 review

Routine scale and polish at a fixed interval vs No scheduled scale and polish treatment

Probing pocket depth · Dentate adults without severe periodontitis, regularly attending for dental care in primary care (UK general dental practice)

Planned, regular routine scale and polish (6-monthly; 12-monthly… showed no clear difference in probing depth compared with no scheduled scale and polish treatment (high certainty).

1 finding from 1 review