Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

880 questions · 912 findings · 126 reviews · Headline outcomes only

No studies found 143 · 15.7%GRADE not reported 38 · 4.2%Very low 250 · 27.4%Low 253 · 27.7%Moderate 168 · 18.4%High 60 · 6.6%

Single foetal haemoglobin inducer at any dose or duration vs placebo or usual care

Adverse events · people with non‐transfusion‐dependent β‐thalassaemia

It is very uncertain whether single foetal haemoglobin inducer at any dose or duration changes adverse events compared with usual care or placebo (very low certainty).

1 finding from 1 review

Nap interventions (1/2): Nap at night (single nap opportunity) vs no‐nap

Sleepiness during the night shift, postintervention; · Shift workers
5 findings from 1 review
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Single‐component medication monitoring and adjustment intervention vs control

Incidence of delirium · people at risk of delirium in institutional long‐term care

Single‐component medication monitoring and adjustment intervention probably leads to lower incidence of delirium NH‐CAM compared with control (moderate certainty).

1 finding from 1 review

Single‐component medication monitoring and adjustment intervention vs control

All‐cause mortality · people at risk of delirium in institutional long‐term care

Single‐component medication monitoring and adjustment intervention showed no clear difference in mortality compared with control (moderate certainty).

1 finding from 1 review

Single‐component medication monitoring and adjustment intervention vs control

Falls · people at risk of delirium in institutional long‐term care

Single‐component medication monitoring and adjustment intervention showed no clear difference in falls Fall events compared with control (low certainty).

1 finding from 1 review

Single‐component medication monitoring and adjustment intervention vs control

Hospital admissions · people at risk of delirium in institutional long‐term care

Single‐component medication monitoring and adjustment intervention showed no clear difference in hospital admissions compared with control (moderate certainty).

1 finding from 1 review

Nasal interfaces (single nasal prong, binasal prongs (long or short), or nasal masks) vs face mask

Mortality before hospital discharge · term and preterm infants resuscitated at birth, using positive pressure ventilation

Nasal interfaces (single nasal prong, binasal prongs (long or… showed no clear difference in death before discharge compared with face mask (low certainty).

1 finding from 1 review