Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,270 questions · 1,480 findings · 174 reviews

No studies found 252 · 17%GRADE not reported 405 · 27.4%Very low 301 · 20.3%Low 284 · 19.2%Moderate 174 · 11.8%High 64 · 4.3%

Single‐port laparoscopic hysterectomy vs laparoscopic hysterectomy

Intra‐operative visceral injury (dichotomous) · patients with benign gynaecological disease

It is very uncertain whether single‐port laparoscopic hysterectomy changes intra‐operative visceral injury (dichotomous) compared with laparoscopic hysterectomy (very low certainty).

1 finding from 1 review

160/4.5 mcg BDF single inhaler therapy vs current best practice

Hospital admissions due to exacerbations: number of participants · adults with asthma not well controlled on ICS

160/4.5 mcg BDF single inhaler therapy showed no clear difference in patients with exacerbations causing hospitalisation compared with current best practice (low certainty).

1 finding from 1 review

160/4.5 mcg BDF single inhaler therapy vs current best practice

Rate of exacerbations requiring systemic corticosteroids · adults with asthma not well controlled on ICS

160/4.5 mcg BDF single inhaler therapy probably leads to lower patients with exacerbations treated with oral steroids compared with current best practice (moderate certainty).

1 finding from 1 review

160/4.5 mcg BDF single inhaler therapy vs current best practice

Fatal serious adverse events · adults with asthma not well controlled on ICS

160/4.5 mcg BDF single inhaler therapy showed no clear difference in fatal serious adverse events compared with current best practice (low certainty).

1 finding from 1 review

160/4.5 mcg BDF single inhaler therapy vs current best practice

Non‐fatal serious adverse events · adults with asthma not well controlled on ICS

160/4.5 mcg BDF single inhaler therapy showed no clear difference in serious adverse events (non‐fatal) compared with current best practice (low certainty).

1 finding from 1 review

160/4.5 mcg BDF single inhaler therapy vs current best practice

Withdrawals due to adverse events · adults with asthma not well controlled on ICS

160/4.5 mcg BDF single inhaler therapy probably leads to higher discontinuation due to adverse events compared with current best practice (moderate certainty).

1 finding from 1 review

Single‐component hydration intervention vs control

Incidence of delirium · people at risk of delirium in institutional long‐term care

It is very uncertain whether single‐component hydration intervention changes incidence of delirium NEECHAM Confusion Scale compared with control (very low certainty).

1 finding from 1 review

Single-strand superelastic NiTi arch wire vs Coaxial superelastic NiTi arch wire

Alignment rate · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)

Single-strand superelastic NiTi arch wire probably leads to lower alignment rate compared with coaxial superelastic NiTi arch wire (moderate certainty).

1 finding from 1 review