Cochrane · systematic review · CD014573
Oral killed cholera vaccines for preventing cholera
Saif-Ur-Rahman, K, Mamun, R, Hasan, M, et al. · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 12.5%High 7 · 87.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
WC‐rBS vaccine (Dukoral): two doses ± booster dose versus placebo
Population: healthy children and adults; high risk population
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cases of cholera ( WC‐rBS vaccine (Dukoral): two doses ± booster dose vs placebo | no estimate extracted | 2 studies · 16423 participants | High |
BivWC vaccine (Shanchol): two doses versus placebo
Population: healthy children and adults; high risk population
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cases of cholera ( BivWC vaccine (Shanchol): two doses vs placebo | no estimate extracted | 1 study · 54519 participants | High |
Cases of cholera ( BivWC vaccine (Shanchol): two doses vs placebo | no estimate extracted | 2 studies · 168540 participants | Moderate Downgraded: inconsistency |
Cases of cholera ( BivWC vaccine (Shanchol): two doses vs placebo | no estimate extracted | 2 studies · 241631 participants | High |
BivWC vaccine (Shanchol): single dose versus placebo
Population: healthy children and adults, male and female; high risk population
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cases of cholera ( BivWC vaccine (Shanchol): single dose vs placebo | no estimate extracted | 1 study · 204700 participants | High |
Cases of severe dehydrating cholera ( BivWC vaccine (Shanchol): single dose vs placebo | no estimate extracted | 1 study · 204700 participants | High |
Cases of cholera ( BivWC vaccine (Shanchol): single dose vs placebo | no estimate extracted | 1 study · 204700 participants | High |
Cases of severe dehydrating cholera ( BivWC vaccine (Shanchol): single dose vs placebo | no estimate extracted | 1 study · 204700 participants | High |