Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

407 questions · 412 findings · 45 reviews · Headline outcomes only

No studies found 137 · 33.3%GRADE not reported 8 · 1.9%Very low 129 · 31.3%Low 88 · 21.4%Moderate 47 · 11.4%High 3 · 0.7%

Any intervention vs artificial tears or saline

Proportion of participants in whose eyes SEIs had developed within 30 days of treatment initiation (lower is favored) · epidemic keratoconjunctivitis

It is very uncertain whether any intervention changes proportion of participants in whose eyes SEIs had developed within… compared with artificial tears or saline (very low certainty).

1 finding from 1 review

Any intervention vs artificial tears or saline

Proportion of participants in whose eyes SEI had disappeared within 21 days of treatment (higher is favored) · epidemic keratoconjunctivitis

It is very uncertain whether any intervention changes proportion of participants in whose eyes SEI had disappeared within… compared with artificial tears or saline (very low certainty).

1 finding from 1 review

Dornase alfa vs hypertonic saline

FEV1 · children with cystic fibrosis

Dornase alfa may leads to higher mean relative percentage in FEV1 (L) at 3 months compared with hypertonic saline (low certainty).

1 finding from 1 review

Dornase alfa vs hypertonic saline

Mean relative percentage in FVC (L) at 3 months · children with cystic fibrosis

Dornase alfa showed no clear difference in mean relative percentage in FVC (L) at 3 months compared with hypertonic saline (low certainty).

1 finding from 1 review

Dornase alfa vs hypertonic saline

Mean relative percentage in quality of life score at 3 months · children with cystic fibrosis

Dornase alfa showed no clear difference in mean relative percentage in quality of life score at 3 months compared with hypertonic saline (low certainty).

1 finding from 1 review