Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

480 questions · 484 findings · 52 reviews · Musculoskeletal

No studies found 114 · 23.6%GRADE not reported 24 · 5%Very low 33 · 6.8%Low 145 · 30%Moderate 116 · 24%High 52 · 10.7%

Celecoxib vs placebo

Short‐term serious adverse events · patients with rheumatoid arthritis

Celecoxib showed no clear difference in short‐term serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Celecoxib vs placebo

Total number of withdrawals · patients with rheumatoid arthritis

Celecoxib may leads to lower total withdrawals; compared with placebo (low certainty).

1 finding from 1 review

Therapeutic ultrasound vs placebo

Global assessment of treatment success · Rotator cuff disease (diagnostic label: calcific tendinitis)

Therapeutic ultrasound may leads to higher global assessment of treatment success compared with placebo (low certainty).

1 finding from 1 review

Balneotherapy vs placebo

Improvement Yes/no based on 5 outcome measures (> 30% reduction in number of swollen joints, > 30% reduction in number of tender joints, > 20% improvement in patient VAS for severity of pain and > 20% improvement in physician VAS) · patients with rheumatoid arthritis

It is very uncertain whether balneotherapy changes improvement Yes/no based on 5 outcome measures (> 30% reduction in… compared with placebo (very low certainty).

1 finding from 1 review