Metformin probably leads to higher ovulation rate per woman compared with placebo or no treatment (moderate certainty).
Metformin showed no clear difference in miscarriage rate per woman compared with placebo or no treatment (low certainty).
Combined continuous hormone therapy (HT) probably leads to higher coronary events (MI or cardiac death) compared with placebo (moderate certainty).
Oestrogen‐only hormone therapy (HT) probably leads to higher venous thromboembolism (DVT or PE) compared with placebo (moderate certainty).
Oestrogen‐only hormone therapy (HT) showed no clear difference in venous thromboembolism (DVT or PE): CEE 0.625 mg (moderate dose) compared with placebo (moderate certainty).
Oestrogen‐only hormone therapy (HT) showed no clear difference in breast cancer compared with placebo (moderate certainty).
Oestrogen‐only hormone therapy (HT) probably leads to higher gallbladder disease compared with placebo (moderate certainty).
Oestrogen‐only hormone therapy (HT) probably leads to lower all clinical fractures compared with placebo (moderate certainty).
Combined continuous hormone therapy (HT) probably leads to higher stroke compared with placebo (moderate certainty).
Combined continuous hormone therapy (HT) probably leads to higher venous thromboembolism (DVT or PE) compared with placebo (moderate certainty).
Combined continuous hormone therapy (HT) probably leads to higher breast cancer compared with placebo (moderate certainty).
Combined continuous hormone therapy (HT) probably leads to higher death from lung cancer compared with placebo (moderate certainty).
Combined continuous hormone therapy (HT) probably leads to higher gallbladder disease compared with placebo (moderate certainty).
Combined continuous hormone therapy (HT) probably leads to lower all clinical fractures compared with placebo (moderate certainty).
Oestrogen‐only hormone therapy (HT) showed no clear difference in coronary events (MI or cardiac death) compared with placebo (moderate certainty).
Oestrogen‐only hormone therapy (HT) probably leads to higher stroke compared with placebo (moderate certainty).
Antibiotics may leads to lower total postoperative infections ‐ early and late compared with placebo (low certainty).
Antibiotics probably leads to lower pelvic infection compared with placebo (moderate certainty).
It is very uncertain whether antibiotics changes other serious infections compared with placebo (very low certainty).
Antibiotics probably leads to lower postoperative fever compared with placebo (moderate certainty).