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What do systematic reviews say?

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Evidence found and GRADE certainty

4,710 questions · 14,842 findings · 1,394 reviews

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No studies found 2,880 · 19.4%GRADE not reported 1,413 · 9.5%Very low 3,103 · 20.9%Low 3,870 · 26.1%Moderate 2,663 · 17.9%High 913 · 6.2%

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Methotrexate vs placebo

Global well‐being: rated by participants · children and young people with JIA

Methotrexate showed no clear difference in participant global assessment of well‐being(up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Serious adverse events(up to 6 months) · children and young people with JIA

Methotrexate showed no clear difference in serious adverse events(up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Withdrawals due to adverse events · children and young people with JIA

Methotrexate showed no clear difference in withdrawals due to adverse events (up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ Protein, arginine, zinc and antioxidants vs standard diet or placebo

The proportion of pressure ulcers healed · residents of long‐term care (≥ 65 years) with pressure ulcers; inpatients with pressure ulcers

It is very uncertain whether summary of findings table ‐ Protein, arginine, zinc and antioxidants changes pressure ulcers healed compared with standard diet or placebo (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Protein, arginine, zinc and antioxidants vs standard diet or placebo

Time to complete healing of pressure ulcers ‐ not reported · residents of long‐term care (≥ 65 years) with pressure ulcers; inpatients with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Protein, arginine, zinc and antioxidants vs standard diet or placebo

Acceptability of nutritional supplements ‐ not reported · residents of long‐term care (≥ 65 years) with pressure ulcers; inpatients with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Protein, arginine, zinc and antioxidants vs standard diet or placebo

Gastrointestinal adverse events · residents of long‐term care (≥ 65 years) with pressure ulcers; inpatients with pressure ulcers

It is very uncertain whether summary of findings table ‐ Protein, arginine, zinc and antioxidants changes side effects: at least one adverse gastrointestinal event compared with standard diet or placebo (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Collagen vs standard diet or placebo

Adverse effects/events: at least 1 adverse effect ‐ as defined by individual studies. · adults with pressure ulcers

It is very uncertain whether summary of findings table ‐ Collagen changes side effects: at least one adverse event compared with standard diet or placebo (very low certainty).

1 finding from 1 review