Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,156 questions · 1,179 findings · 198 reviews · Headline outcomes only

No studies found 250 · 21.2%GRADE not reported 43 · 3.6%Very low 236 · 20%Low 395 · 33.5%Moderate 208 · 17.6%High 47 · 4%

Cilostazol vs pentoxifylline

Adverse event related to study medication ‐ headache (number of cases) · intermittent claudication

Cilostazol may leads to higher adverse event related to study medication ‐ headache (number of cases) compared with pentoxifylline (low certainty).

1 finding from 1 review

Cilostazol vs placebo

Adverse event related to study medication ‐ headache (number of cases) · intermittent claudication

Cilostazol probably leads to higher adverse event related to study medication ‐ headache (number of cases) compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Additional medications required · adults with PACS or PAC, and previous PI

The review found no eligible studies for this question.

1 finding from 1 review

Discontinuing cholinesterase inhibitor vs continued cholinesterase inhibitor

Dropout due to lack of efficacy of trial medication or deterioration in overall medical condition · people with dementia

Discontinuing cholinesterase inhibitor showed no clear difference in dropout due to lack of efficacy of trial medication or deterioration… compared with continued cholinesterase inhibitor (low certainty).

1 finding from 1 review

Primary health professional‐led or collaborative care vs specialist‐led care

Relapse of severe mental disorder (immediately post intervention) Defined by re‐appearance of symptoms or worsening of symptoms necessitating adjustment of medicationa; Li 2002; based on 1 item scoring ≥ 5 or 2 items scoring ≥ 4 in items 4, 7, 11,... · people with severe mental disorders

It is very uncertain whether primary health professional‐led or collaborative care changes relapse of severe mental disorder (immediately post intervention)… compared with specialist‐led care (very low certainty).

1 finding from 1 review

Phaco‐AIT vs Phaco‐Trab

Proportion of participants who were medication‐free (not using drops) at 12 months · people with open‐angle glaucoma

It is very uncertain whether phaco‐AIT changes proportion of participants who were medication‐free (not using… compared with phaco‐Trab (very low certainty).

1 finding from 1 review

Phacoemulsification + supraciliary microstent surgery vs phacoemulsification alone

Proportion of participants who were medication‐free (not using eye drops) medium‐term · people with open‐angle glaucoma

Phacoemulsification + supraciliary microstent surgery probably leads to higher proportion of participants who were medication‐free (not using… compared with phacoemulsification alone (moderate certainty).

1 finding from 1 review

Phacoemulsification + supraciliary microstent surgery vs phacoemulsification alone

Mean change in daily IOP‐lowering medicationsat 24 months (medium‐term) · people with open‐angle glaucoma

Phacoemulsification + supraciliary microstent surgery showed no clear difference in mean change in daily IOP‐lowering medicationsat 24 months… compared with phacoemulsification alone (moderate certainty).

1 finding from 1 review

Nifedipine vs placebo

Requirement for additional medication · primary dysmenorrhoea

It is very uncertain whether nifedipine changes requirement for additional medication compared with placebo (very low certainty).

1 finding from 1 review

Intravenous ketorolac vs NSAIDs

Number of women requiring rescue medication · adults (mean study ages 23 to 67 years) with acute postoperative pain after abdominal/pelvic, dental or orthopedic surgeries

It is very uncertain whether intravenous ketorolac changes number of participants using rescue medication over 4 or 6 hours… compared with another NSAID (very low certainty).

1 finding from 1 review