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Evidence found and GRADE certainty

1,266 questions · 1,314 findings · 160 reviews · Headline outcomes only

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No studies found 309 · 23.5%GRADE not reported 34 · 2.6%Very low 356 · 27.1%Low 393 · 29.9%Moderate 187 · 14.2%High 35 · 2.7%

Antidepressants vs placebo

Adverse events ‐ Withdrawn for medical reasons · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants probably leads to higher adverse events ‐ Withdrawn for medical reasons compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events ‐ Withdrawn for medical reasons: Tricyclics versus placebo · patients with depression during opioid agonist treatment for opioid dependence

The intervention leads to higher adverse events ‐ Withdrawn for medical reasons: Tricyclics versus… (high certainty).

1 finding from 1 review

Intervention not reported

Adverse events ‐ Withdrawn for medical reasons: SSRI versus placebo · patients with depression during opioid agonist treatment for opioid dependence

The intervention showed no clear difference in adverse events ‐ Withdrawn for medical reasons: SSRI versus placebo (high certainty).

1 finding from 1 review

Antidepressants vs placebo according to any definition

Adverse events ‐ Withdrawn for medical reasons · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants probably leads to higher adverse events ‐ Withdrawn for medical reasons compared with placebo according to any definition (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Adverse event nausea and vomiting (0 to 24 hours) · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in gastrointestinal side effects (nausea and/or vomiting) compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

1 finding from 1 review

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Complete abortion rate · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in complete abortion rate compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

1 finding from 1 review

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Unscheduled contact with care · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in unscheduled contact with care compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

1 finding from 1 review

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Patient satisfaction with abortion care overall ‐ not reported · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in patient satisfaction with abortion care overall compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

1 finding from 1 review

Summary of findings for the main comparison: comprehensive care programmes vs usual care

Parent health, functioning, and quality of life Patient‐Reported Outcomes Measurement Information System (PROMIS) (higher scores = more of the outcome of interest, which can mean improvement or deterioration depending on the outcome) · children with medical complexity
1 finding from 1 review

Summary of findings for the main comparison: comprehensive care programmes vs usual care

Child and family satisfaction with, and perceptions of, care and service delivery Family Experiences With Coordination of Care (FECC) survey (higher scores = better) Consumer Assessment of Healthcare Providers and Systems (CAHPS) (higher scores = ... · children with medical complexity
1 finding from 1 review