Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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Chemotherapy vs placebo, best supportive care (BSC) or no treatment

Progression‐free survival · advanced gastric and oesophago‐gastric junction adenocarcinoma

Chemotherapy leads to lower progression‐free survival compared with placebo, best supportive care (BSC) or no treatment (high certainty).

1 finding from 1 review

Chemotherapy vs placebo, best supportive care (BSC) or no treatment

Serious adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

Chemotherapy probably leads to higher serious adverse events compared with placebo, best supportive care (BSC) or no treatment (moderate certainty).

1 finding from 1 review

Chemotherapy vs placebo, best supportive care (BSC) or no treatment

Tumour response · advanced gastric and oesophago‐gastric junction adenocarcinoma

Chemotherapy showed no clear difference in tumour response rate compared with placebo, best supportive care (BSC) or no treatment (low certainty).

1 finding from 1 review

Chemotherapy vs placebo, best supportive care (BSC) or no treatment

Any adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

Chemotherapy showed no clear difference in any adverse events compared with placebo, best supportive care (BSC) or no treatment (high certainty).

1 finding from 1 review

Iron therapy vs No treatment, placebo, usual care, or another oral care measure

Haemoglobin (g/dL) · people with preoperative anaemia awaiting major surgery

Iron therapy showed no clear difference in haemoglobin levels at end of preoperative treatment (g/dL) compared with placebo, no treatment or standard care (low certainty).

2 findings from 1 review

Aromatherapy vs placebo

Nausea duration (nausea‐free at end of treatment) Measured by participant self‐report or medical or nursing observation · adults and children having any type of surgical procedure under general anaesthesia, regional anaesthesia or sedation, as hospital…

It is very uncertain whether aromatherapy changes nausea duration (nausea‐free at end of treatment) Assessed by… compared with placebo (very low certainty).

1 finding from 1 review

Aromatherapy vs placebo

Rescue antiemetic · adults and children having any type of surgical procedure under general anaesthesia, regional anaesthesia or sedation, as hospital…

Aromatherapy may leads to lower proportion requiring rescue antiemetics Assessed by numbers of… compared with placebo (low certainty).

1 finding from 1 review

Aromatherapy vs placebo

Patient satisfaction with treatment Measured by a validated scale · adults and children having any type of surgical procedure under general anaesthesia, regional anaesthesia or sedation, as hospital…

The review found no eligible studies for this question.

1 finding from 1 review

Dinutuximab‐containing immunotherapy vs usual care

Overall survival (reported as mortality) · People with high‐risk neuroblastoma pre‐treated with autologous haematopoietic stem cell transplantation

Dinutuximab‐containing immunotherapy probably leads to lower overall survival (reported as mortality) compared with standard therapy (moderate certainty).

1 finding from 1 review

Dinutuximab‐containing immunotherapy vs usual care

Treatment‐related mortality ‐ not reported · People with high‐risk neuroblastoma pre‐treated with autologous haematopoietic stem cell transplantation

The review found no eligible studies for this question.

1 finding from 1 review