Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,017 questions · 1,061 findings · 131 reviews

No studies found 193 · 18.2%GRADE not reported 65 · 6.1%Very low 237 · 22.3%Low 325 · 30.6%Moderate 187 · 17.6%High 54 · 5.1%

Intravenous tranexamic acid vs placebo

Risk of suspected serious drug reactions (30 days post‐surgery) · people undergoing definitive fixation of hip, pelvic and long bone fractures

It is very uncertain whether intravenous tranexamic acid changes risk of suspected serious drug reactions (30 days post‐surgery) compared with placebo (very low certainty).

1 finding from 1 review

Reslizumab intravenous (IV) vs placebo

Rate of clinically significant exacerbations requiring systemic corticosteroids · people with asthma

Reslizumab intravenous (IV) leads to lower rate of clinically significant exacerbations requiring systemic… compared with placebo (high certainty).

1 finding from 1 review

Reslizumab intravenous (IV) vs placebo

Rate of exacerbations requiring emergency department treatment or admission · people with asthma

Reslizumab intravenous (IV) showed no clear difference in rate of exacerbations requiring emergency department treatment or… compared with placebo (high certainty).

1 finding from 1 review

Reslizumab intravenous (IV) vs placebo

Serious adverse events · people with asthma

Reslizumab intravenous (IV) showed no clear difference in serious adverse events compared with placebo (high certainty).

1 finding from 1 review

Reslizumab intravenous (IV) vs placebo

Clinically significant adverse events leading to discontinuation · people with asthma

Reslizumab intravenous (IV) showed no clear difference in clinically significant adverse events leading to discontinuation compared with placebo (high certainty).

1 finding from 1 review

Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping

Maternal composite morbidity · women undergoing caesarean section

Prophylactic intravenous antibiotics administered before cesarean… leads to lower maternal composite morbidity compared with after neonatal umbilical cord clamping (high certainty).

1 finding from 1 review

Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping

Endomyometritis · women undergoing caesarean section

Prophylactic intravenous antibiotics administered before cesarean… leads to lower maternal endomyometritis compared with after neonatal umbilical cord clamping (high certainty).

1 finding from 1 review

Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping

Wound infection · women undergoing caesarean section

Prophylactic intravenous antibiotics administered before cesarean… leads to lower maternal wound Infection compared with after neonatal umbilical cord clamping (high certainty).

1 finding from 1 review

Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping

Maternal UTI/cystitis/pyelonephritis · women undergoing caesarean section

Prophylactic intravenous antibiotics administered before cesarean… showed no clear difference in maternal UTI/cystitis/pyelonephritis compared with after neonatal umbilical cord clamping (moderate certainty).

1 finding from 1 review

Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping

Maternal respiratory infection (pneumonia) · women undergoing caesarean section

Prophylactic intravenous antibiotics administered before cesarean… showed no clear difference in maternal respiratory infection (pneumonia) compared with after neonatal umbilical cord clamping (low certainty).

1 finding from 1 review

Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping

Neonatal sepsis · women undergoing caesarean section

Prophylactic intravenous antibiotics administered before cesarean… showed no clear difference in neonatal sepsis compared with after neonatal umbilical cord clamping (moderate certainty).

1 finding from 1 review

Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping

Admission to neonatal intensive care unit · women undergoing caesarean section

Prophylactic intravenous antibiotics administered before cesarean… showed no clear difference in neonatal ICU admission compared with after neonatal umbilical cord clamping (high certainty).

1 finding from 1 review