Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

375 questions · 390 findings · 22 reviews · Pain, Palliative and Supportive Care

No studies found 117 · 30%GRADE not reported 36 · 9.2%Very low 111 · 28.5%Low 75 · 19.2%Moderate 48 · 12.3%High 3 · 0.8%

NSAIDs vs placebo

Patient Global Impression of Change much or very much improved · adults with sickle cell disease in a vaso‐occlusive crisis

It is very uncertain whether non‐steroidal anti‐inflammatory drugs (NSAID) changes PGIC much or very much improved ( compared with placebo (very low certainty).

1 finding from 1 review